研究・業績

原著論文

2024年

Validation of an automated sample preparation module directly connected to LC-MS/MS (CLAM-LC-MS/MS system) and comparison with conventional immunoassays for quantitation of tacrolimus and cyclosporin A in a clinical setting.
Shimada T, Kawakami D, Fujita A, Yamamoto R, Hara S, Ito K, Mizushima I, Kitajima S, Iwata Y, Sakai N, Kawano M, Wada T, Sai Y.
J Pharm Health Care Sci.10:5 (2024) Jan 1, doi.org/10.1186/s40780-023-00318-6

Sodium citrate buffer improves pazopanib solubility and absorption in gastric acid-suppressed rat model.
Muhammad HJ, Shimada T, Fujita A, Sai Y.
Drug Metab Pharmacokinet, In Press doi.org/10.1016/j.dmpk.2024.100995

2023年

Application Site of Transdermal Scopolamine Influences Efficacy and Drug Concentration in Salivary Glands in Rats
Ishida N, Oshima Y, Katsura A, Imamura R, Arakawa H, Shimada T, Mizuno S, Sai Y, Suga Y, Matsushita R.
Biol Pharm Bull. 46(12):1805-1809. (2023) DOI 10.1248/bpb.b23-00561

Association between switching prescribed drugs for lower urinary tract symptoms and independence of urination in post-stroke patients: A retrospective cohort study
Sumiya K, Shogenji M, Ikenaga Y, Ogawa Y, Hirako K, Fujita A, Shimada T, Hashimoto M, Masuda A, Nagamoto T, Tamai I, Ogura H, Toyama T, Wada T, Sai Y.
J Stroke Cerebrovasc Dis. 32(12).107419 (2023) doi.org/10.1016/j.jstrokecerebrovasdis.2023.107419

Case report: therapeutic monitoring of vancomycin in an acute liver failure patient with anuria under high-flow continuous hemodiafiltration
Ito Y, Nakade J, Seki A, Gabata R, Okazaki M, Nakanuma S, Fujita A, Shimada T, Yamashita T, Yagi S, Taniguchi T, Sai Y
J Pharm Health Care Sci. 9:15. 2023 May 1 doi.org/10.1186/s40780-023-00283-0

Impact of antithymocyte globulin on blood cyclosporin A levels in aplastic anemia patients.
Futagi Y, Suga Y, Shimada T, Sai Y.
Ann Hematol. 102(2):463-465. (2023) Feb doi: 10.1007/s00277-022-05063-8.

Systematic active environmental surveillance successfully identified and controlled the Legionella contamination in the hospital
Nakade J, Nakamura Y, Katayama Y, Obata H, Takahashi Y, Zaimoku Y, Fuji Y, Iwata Y
J Infect Chemother 29(1):43-47. (2023) Jan; doi: 10.1016/j.jiac.2022.09.010.

2022年

Evaluation of factors affecting epidermal growth factor receptor tyrosine kinase inhibitor-induced hepatotoxicity in Japanese patients with non-small cell lung cancer: a two-center retrospective study
Nagai H, Shimada T, Takahashi Y, Nishikawa M, Tozuka H, Yamamoto Y, Niwa O, Takahara Y, Fujita A, Nagase K, Kasahara K, Yano S, Sai Y.
J Pharm Health Care Sci. 8(1):28. 2022 Dec 1 doi: 10.1186/s40780-022-00258-7.

Single-Center Analysis of Pegfilgrastim-induced Aortitis Using a Drug Prescription Database and CT Findings.
Takamatsu A, Yoshida K, Toshima F, Kozaka K, Yamamoto N, Sai Y, Gabata T
Radiology. 305(3):729-740. 2022 Dec doi: 10.1148/radiol.220357

Ceftriaxone-induced encephalopathy in a patient with a solitary kidney.
Futagi Y, Ito Y, Nakade J, Fujita A, Shimada T, Yoshida M, Takahashi Y, Kawano M, Taniguchi T, Sai Y.
Int J Infect Dis, S1201-9712(22)00431-3. (2022) Jul 14 doi: 10.1016/j.ijid.2022.07.036.

Quantitative Comparison of Breast Cancer Resistance Protein (BCRP/ABCG2) Expression and Function Between Maternal Blood-Brain Barrier and Placental Barrier in Mice at Different Gestational Ages.
Fujita A, Noguchi S, Hamada R, Shimada T, Katakura S, Maruyama T, Sai Y, Nishimura T, Tomi M.
Front. Drug. Deliv., 2,93257622(2022) Jul doi.org/10.3389/fddev.2022.932576

Relationship between Bowel/Bladder Function and Discharge in Older Stroke Patients in Convalescent Rehabilitation Wards: A Retrospective Cohort Study
Shogenji M, Yoshida M, Sumiya K, Shimada T, Ikenaga Y, Ogawa Y, Hirako K, Sai Y
Prog. Rehabil. Med.7, 20220028 (2022) doi: 10.2490/prm.20220028

Association of a continuous continence self-management program with independence in voiding behavior among stroke patients: A retrospective cohort study
Shogenji M, Yoshida M, Sumiya K, Shimada T, Ikenaga Y, Ogawa Y, Hirako K, Sai Y
Neurourol Urodyn. 2022;1-12. doi:10.1002/nau.24922

Effects of eicosapentaenoic acid on serum levels of selenoprotein P and organ-specific insulin sensitivity in humans with dyslipidemia and type 2 diabetes.
Takeshita Y, Teramura C, Kamoshita K, Takayama H, Nakagawa H, Enyama Y, Ishii K, Tanaka T, Goto H, Nakano Y, Osada S, Tanaka Y, Tokuyama K, Takamura T
J Diabetes Investig. 13(3):532-542 (2022) Mar doi: 10.1111/jdi.13699.

Risk factors for interstitial lung disease induced by gemcitabine plus albumin-bound paclitaxel therapy in pancreatic ductal adenocarcinoma patients
Ueda R, Yamamoto N, Hori Y, Yoshida K, Ohtsubo K, Terashima T, Shimada T, Sai Y
J Pharm Health Care Sci 8:5 (2022) 2 Feb. https://doi.org/10.1186/s40780-021-00236-5

Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers
Fujita A, Noguchi S, Hamada R, Inoue S, Shimada T, Katakura S, Maruyama T, Sai Y, Nishimura T, Tomi M
Pharm Res 39(7):1645-1658. (2022) Jul; doi: 10.1007/s11095-022-03165-6.

2021年

Oxytocin-Trust Link in Oxytocin-Sensitive Participants and Those without Autistic Traits.
Kinari Y, Kurokawa H, Okudaira H, Tsubouchi K, Sai Y, Kikuchi M, Higashida H, Ohtake F.
Frontiers in Neuroscience, section Neuroendocrine Science. (2021). May 25. PMID:34113232 https://doi.org/10.3389/fnins.2021.659737

Initial Serum C-reactive Protein Level as a Predictor of Increasing Serum Vancomycin Concentration During Treatment
Isoda K, Nakade J, Suga Y, Fujita A, Shimada T, Sai Y
Ther Drug Monit. 43(5), 652-656 (2021) doi: 10.1097/FTD.0000000000000870..

Effect of NOS Inhibitors and Anticoagulants on Nitric Oxide Production in a Tissue-factor Induced Rat DIC Model
Suga Y, Takahashi Y, Shimada T, Yamada S, Morishita E, Asakura H
In Vivo. 35(4):1999-2004 (2021) doi: 10.21873/invivo.12468.

2020年

A previously unknown drug-drug interaction is suspected in delayed elimination of plasma
methotrexate in high-dose methotrexate therapy.
Ishizaki J, Nakano C, Kitagawa K, Suga Y, Sai Y.
Ann Pharmacother. 54 (1):29-35 (2020). Jan, doi:10.1177/1060028019870445.

Competitiveness and individual characteristics: a double-blind placebo-controlled study using oxytocin.
Kurokawa H, Kinari Y, Okudaira H, Tsubouchi K, Sai Y, Kikuchi M, Higashida H, Ohtake F.
Sci Rep. 10 (1):11526 (2020). Jul 13 doi: 10.1038/s41598-020-68445-w.

ルーブリックを活用したAROモニターの育成（Case Report）
川上 貴裕、堀川 尚嗣、長瀬 克彦、崔　吉道、村山 敏典
薬理と治療 48 suppl 2 :s1-s 5（2020）.

Risk Factors for Delayed Elimination of Methotrexate in Children, Adolescents and Young Adults With Osteosarcoma
Misaka K, Suga Y, Staub Y, Tsubata A, Shimada T, Sai Y, Matsushita R3
In Vivo. 34(6), 3459-3465 (2020) doi: 10.21873/invivo.12185.

Administration of erlotinib in apple juice overcomes decreased absorption in a rat model of gastric acid suppression
Shimada T, Okano M, Yamada M, Ogawa Y, Ueda A, Nagake K, Yoshimichi Sai
Drug Metab Pharmacokinet 35(6), 534-538 (2020) doi:org/10.1016/j.dmpk.2020.08.003

Comparison of Tolerability Between 2-Weekly and 3-Weekly Docetaxel Regimen in Castration-resistant Prostate Cancer
Shimura Y, Suga Y, Itai S, Iwamoto H, Takezawa Y, Yaegashi H, Izumi K, Shimada T, Sai Y, Matsushita R, Mizokami A
Anticancer Res 40(8),4291-4297 (2020) doi:10.21873/anticanres.14431

The active ingredients in the anti-obesity drugbofutsushosan in high-fat-diet-fed obese mice
Takahashi T, Hori K, Yoshida E, Ikeda-Matsuo Y, Shimada T, Nomura M, Kobayashi S
Traditional & Kampo Medicine (2020) doi.org/10.1002/tkm2.1253

個別認証技術を用いた医療用麻薬フェンタニル注射液の院内個別管理
嶋田　努，長田幸恵，原　祐輔，登　真良，旭野欣也，牧野智成，崔　吉道
医療薬学雑誌46(5), 249-256 (2020).

Examination of Aggregate Formation upon Simultaneous Dissolution of Methacrylic Acid Copolymer LD Enteric Coating Agent, Pharmaceutical Additives, and Zwitterionic Ingredients
Nakagawa Y, Suzuki T, Suga Y, Shimada Y, Sai Y
Biol. Pharm. Bull 43, 682-687 (2020) doi.org/10.1248/bpb.b19-00924　★ Featured Articleに選出

東京都におけるRSV感染症の流行期間の探索的検討
山上英臣, 木村博一, 三上修, 橋本孝史, 草川功, 楠田　聡
PROGRESS IN MEDICINE 40: 83-88 (2020).

Severe intoxication caused by sodium-glucose cotransporter 2 inhibitor overdose: a case report
Nakamura M, Nakade J, Toyama T, Okajima M, Taniguchi T
BMC Pharmacology and Toxicology 21:5 (2020) doi.org/10.1186/s40360-019-0381-z

2019年

The clinical course and potential underlying mechanisms of everolimus-induced hyperglycemia.
Tanimura J, Nakagawa H, Tanaka T, Kikuchi A, Osada S, Tanaka Y, Tokuyama K, Takamura T
Endocr J 66(7):615-620 (2019) Jul 28 doi: 10.1507/endocrj.EJ18-0542.

Detection of the Onset of the Epidemic Period of Respiratory Syncytial Virus Infection in Japan.
Yamagami H, Kimura H, Hashimoto T, Kusakawa I, Kusuda S.
Front Public Health. 7,39. (2019) doi: 10.3389/fpubh.2019.00039. eCollection 2019.

Effects of combined treatment with fesoterodine and mirabegron in a pelvic congestion rat model: Results from in vitro and in vivo functional studies.
Sugaya K, Yamagami H, Nishijima S, Kadekawa K, Hizue M, Ito Y, Yamada S.Low Urin
Tract Symptoms. (2019) doi: 10.1111/luts.12296.

Detailed assessment and risk factor analysis of corticosteroid-induced psychiatric disorders in pediatric, adolescent, and young adult patients undergoing induction or consolidation therapy for hematologic malignancy.
Staub Y, Suga Y, Ikawa Y, Tsubouchi K, Hashimoto M, Kawagishi A, Shimada T, Sai Y, Nishimura K, Matsushita R.
J Oncol Pharm Pract. 2019 Oct 21:1078155219879992. doi: 10.1177/1078155219879992. [Epub ahead of print]

Improvement of Informed Consent Document Management in Clinical Trials Using an Electronic Medical Record System
Kawakami T, Nagase K, Yokoi Y, Sai Y, Murayama T
Jpn J Clin Pharmacol Ther(臨床薬理) 50(3):81-86.

Incidence and risk factors of neonatal hypoglycemia after ritodrine therapy in premature labor: a retrospective cohort study
Shimokawa S, Sakata A, Suga Y, Isoda K, Itai S, Nagase K, Shimada T, Sai Y.
J Pharm Health Care Sci 5:7 (2019) 16 April. doi.org/10.1186/s40780-019-0137-3

Palonosetron on Days 1 and 5 Versus Granisetron Daily (Days 1-5) in Germ Cell Tumour Therapy.
Shimura Y, Izumi K, Itai S, Iwamoto H, Yaegashi H, Suga Y, Shimada T, Mizokami A, Sai Y.
In Vivo. 33:643-647 (2019) Mar-Apr, doi: 10.21873/invivo.11522.

Multiday corticosteroids in cancer chemotherapy delay the diagnosis of and antimicrobial administration for febrile neutropenia: a double-center retrospective study
Uda H, Suga Y, Toriba E, Staub AY, Shimada T, Sai Y, Kawahara M, Matsusita R
J Pharm Health Care Sci. 5:3 (2019) 4 Feb. doi.org/10.1186/s40780-018-0130-2

Hatano rats are a suitable metabolic syndrome model for studying feeding behavior, blood pressure levels, and percent body fat.
Isobe A, Shimada T, Aburada M, Yanagisawa R, Sakawa T, Nakamura T, Himi T, Ohta R, Kawaguchi M
J Vet Med Sci. 81(1):147-154 (2019) Jan. doi: 10.1292/jvms.18-0342

アルブミン懸濁型パクリタキセル+ゲムシタビン療法における末梢神経障害のリスク因子に関する検討
山本　奈歩，堀　祐貴，高廣　理佳子，菅　幸生，嶋田　努，崔　吉道
医療薬学雑誌45(3)127-134 (2019)

2018年

Effect of coadministration of rifampicin on the pharmacokinetics of linezolid: clinical and animal studies
Hashimoto S, Honda K, Fujita K, Miyachi Y, Isoda K, Misaka K, Suga Y, Kato S, Tsuchiya H, Kato Y, Okajima M, Taniguchi T, Shimada T, Sai Y.
J Pharm Health Care Sci 4:27 (2018) 12 Nov. doi.org/10.1186/s40780-018-0123-1

Risk factors for oxaliplatin-induced vascular pain in patients with colorectal cancer and comparison of the efficacy of preventive methods
SugaY, Ikeda N, Maeda M, Staub AY, Shimada T, Yonezawa M, Kitade H, Katsura H, Okada M, Ishizaki J, Sai Y, Matsushita R
J Pharm Health Care Sci 4:18 (2018) Aug doi.org/10.1186/s40780-018-0117-z

Contribution of equilibrative nucleoside transporters 1 and 2 to gemcitabine uptake in pancreatic cancer cells
Hioki M, Shimada T, Yuan T, Nakanishi T,Tajima H, Yamazaki M, Yokono R, Takabayashi M, Sawamoto K, Akashita G, Miyamoto KI, Ohta T, Tamai I, Shimada T, Sai Y
Biopharm Drug Dispos 39 256-264 (2018) May doi.org/10.1002/bdd.2131

Efficacy and safety of fesoterodine treatment for overactive bladder symptoms in elderly women with and without hypertension.
Yokoyama O, Yamagami H, Hiro S, Hotta S, Yoshida M.
Int J Urol. 25 251-257 (2018) doi: 10.1111/iju.13499.

Effect of Kaempferia parviflora extract on knee osteoarthritis.
Kobayashi H, Suzuki R, Sato K, Ogami T, Tomozawa H, Tsubata M, Ichinose K, Aburada M, Ochiai W, Sugiyama K, Shimada T.
J Nat Med. 72(1) 136-144 (2018) Jan. doi: 10.1007/s11418-017-1121-6.

当院における入院患者由来メチシリン耐性黄色ブドウ球菌（MRSA）型別の変遷について
千田　靖子、岩田　恭宣、坂井　優喜子、中出　順也、中出　祐介、中村　洋子、大谷　初美、前河　晶子、和田　泰三、酒井　佳夫、和田　隆志
臨床病理　66 (11) 1169-1175 (2018)

進行膵がん患者に対するFOLFIRINOX療法施行時におけるコリン様症状の発現状況とリスク因子の探索
伊藤智代，中出順也，嶋田　努，崔　吉道
医療薬学　44（8）403-409 （2018） Jun

診療情報を使用したダウン症候群のRS有為する感染重症化リスク因子の疫学研究
野本　憲、山上　英臣、三山　修、近藤　達郎、森尾　友宏.
Prog. Med 38 531-536 (2018)

RSウイルス感染症流行期の予測とパリビブマブ
山上　英臣、新井田　信彦、三山　修
Bio Clinica 33 (3) 71-76 (2018)

2017年

Multiple Oral Dosing Pharmacokinetics of Standardized Extract of Centella asiatica ECa 233 and Its Inductive Effect on Efflux Transporters in Rats.
Anukunwithaya T, Tantisira MH, Shimada T, Sai Y, Khemawoot P
Planta Medica International Open 4(02): e66-e73 (2017) 06 June DOI: 10.1055/s-0043-114669

Drug interaction between methotrexate and salazosulfapyridine in Japanese patients with rheumatoid arthritis
Morihiro Okada, Hiroshi Fujii, Yukio Suga, Satoshi Morito, Masae Okada, Jun Nishigami, Mitsuhiro Kawano, Tsutomu Shimada and Yoshimichi Sai
Journal of Pharmaceutical Health Care and Sciences 3:7 (2017) Jan DOI 10.1186/s40780-017-0073-z

Co-administration of Dexamethasone Increases Severity and Accelerates Onset Day of Neutropenia in Bladder Cancer Patients on Methotrexate, Vinblastin, Adriamycin and Cisplatin Chemotherapy: A Retrospective Cohort Study
Itai S, Suga Y, Hara Y, Izumi K, Maeda Y, Kitagawa Y, Ishizaki J, Shimada T, Mizokami A, Sai Y
Journal of Pharmaceutical Health Care and Sciences 3:3 (2017) Jan DOI 10.1186/s40780-016-0072-5

ランソプラゾールOD錠とレボフロキサシン錠同時懸濁時における凝集物生成の原因と対策
中川祐紀子，鈴木拓也，志村裕介，菅　幸生，嶋田　努，崔　吉道
医療薬学　43（1）26-33 （2017） Jan

2016年

Oxytocin for male subjects with autism spectrum disorder and comorbid intellectual disabilities: A randomized pilot study
Toshio Munesue,Hiroyuki Nakamura, Mitsuru Kikuchi, Yui Miura, Noriyuki Takeuchi, Tokie Anme, Eiji Nanba, Kaori Adachi, Kiyotaka Tsubouchi, Yoshimichi Sai, Kenichi Miyamoto, Shinichi Horike, Shigeru Yokoyama, Hideo Nakatani, Hirotaka Kosaka, Yoshio Minabe, Haruhiro Higashida
Frontiers Psyc 21 7(2) (2016) Jan

Effects of ethyl acetate extract of Kaempferia parviflora on brown adipose tissue
Kobayashi Y, Horiguchi-Babamoto E, Suzuki M, Makihara H, Tomozawa H, Tsubata M, Shimada T, Sugiyama K, Aburada M,
Journal of Natural Medicines 70(1) 54-61 (2016) Jan

Treatment Outcome of Low-dose Interleukin-2 Therapy in Patients with Metastatic Renal Cell Carcinoma.
Takezawa Y, Izumi K, Shimura Y, Aerken M, Natsagdorji A, Iijima M, Shigehara K, Nohara T, Narimoto K, Kadono Y, Kitagawa Y, Konaka H, Mizokami A.
Anticancer Res. 36 (9):4961-4 (2016). Sep doi: 10.21873/anticanres.11064.

Gallic Acid, the Active Ingredient of Terminalia bellirica, Enhances Adipocyte Differentiation and Adiponectin Secret ion.
Makihara H, Koike Y, Ohta M, Horiguchi-Babamoto E, Tsubata M, Kinoshita K, Akase T, Goshima Y, Aburada M, Shimada T.
Biol Pharm Bull. 39(7):1137-43.　（2016）

Activity of daily living for Morquio A syndrome.
Yasuda E, Suzuki Y, Shimada T, Sawamoto K, Mackenzie WG, Theroux MC, Pizarro C, Xie L, Miller F, Rahman T, Kecskemethy HH, Nagao K, Morlet T, Shaffer TH, Chinen Y, Yabe H, Tanaka A, Shintaku H, Orii KE, Orii KO, Mason RW, Montaño AM, Fukao T, Orii T, Tomatsu S.
Mol Genet Metab. 118(2):111-22. （2016) Jun

2015年

PK/PD analysis of biapenem in patients undergoing continuous hemodiafiltration.
Akashita G, Hosaka Y, Noda T, Isoda K, Shimada T, Sawamoto K, Miyamoto KI, Taniguchi T, Sai Y.
Journal of Pharmaceutical Health Care and Sciences 1:31 (2015) Ｎｏｖ

Effect of switching basal insulin regimen to degludec on quality of life in Japanese patients with type 1 and type 2 diabetes mellitus.
Okada M, Okada M, Nishigami J, Yamaaki N, Furukawa K, Ohyama K, Shimada T, Sai Y.
Journal of Pharmaceutical Health Care and Sciences 1:26 (2015) Sep

Saturable Hepatic Extraction of Gemcitabine Involves Biphasic Uptake Mediated by Nucleoside Transporters Equilibrative Nucleoside Transporter 1 and 2.
Shimada T, Nakanishi T, Tajima H, Yamazaki M, Yokono R, Takabayashi M, Shimada T, Sawamoto K, Miyamoto KI, Kitagawa H, Ohta T, Tamai I, Sai Y.
J Pharm Sci. 104(9): 3162-9, (2015) Sep

Long-term follow-up of post hematopoietic stem cell transplantation for Hurler syndrome: clinical, biochemical, and pathological improvements.
Yasuda E, Mackenzie W, Ruhnke K, Shimada T, Mason RW, Zustin J, Thacker M, Orii T, Sai Y, Tomatsu S.
Mol Genet Metab Rep.2:65-76 (2015) Mar

Neonatal bone marrow transplantation prevents bone pathology in a mouse model of mucopolysaccharidosis type I.
Pievani A, Azario I, Antolini L, Shimada T, Patel P, Remoli C, Rambaldi B, Valsecchi MG, Riminucci M, Biondi A, Tomatsu S, Serafini M.
Blood. 125(10):1662-71 (2015) Mar

Pharmacoeconomic effect of compliance with pharmacist’s intervention based on cancer chemotherapy regimens: a cohort study
Makoto Hayashi, Akimasa Yamatani, Hiromu Funaki, Kenichi Miyamoto
Journal of Pharmaceutical Health Care and Sciences 1:10 (2015) Mar

Glycogen synthase kinase 3β sustains invasion of glioblastoma via the focal adhesion kinase, Rac1 and c-Jun N-terminal kinase-mediated pathway
Chikano Y, Domoto T, Furuta T, Sabit H, Kitano-Tamura A, Pyko IV, Takino T, Sai Y, Hayashi Y, Sato H, Miyamoto K, Nakada M, Minamoto T .
Mol Cancer Ther 14(2):564-574. (2015) Feb

Di-sulfated keratan sulfate as a novel biomarker for mucopolysaccharidosis IVA.
Shimada T, Tomatsu S, Mason RW, Yasuda E, Mackenzie WG, Hossain J, Shibata Y, Montaño AM, Kubaski F, Giugliani R, Yamaguchi S, Suzuki Y, Orii KE, Fukao T, Orii T
J Inherit Metab Dis Reports 21:1-13 (2015) Feb

管理簿を用いたラモトリギンの処方管理と皮膚障害発現リスクの検討
油屋　恵、板井進悟、坪内清貴、有賀文俊、宮地佑佳、中谷絵莉、伊達絢一郎、谷本 定子、前田大蔵、崔　吉道、宮本謙一
日本病院薬剤師会雑誌51(5):533-536 (2015). May

リラグルチドの有害事象による中止の危険因子の探索
板井進悟，菅　幸生，長田幸恵，吉田早稀，渡辺真生，油屋 恵，志村裕介，本谷和佳子，樋口真衣子，伊達絢一郎，橋詰未央，八木邦公，篁 俊成，崔 吉道，武田仁勇，宮本謙一
糖尿病　58 159-166, （2015） Apr

2014年度 (#312-334)

Enantioselective disposition of clenbuterol in rats.
Hirosawa I, Ishikawa M, Ogino M, Ito H, Hirano T, Yamada H, Asahi M, Kotaki H, Sai Y, Miyamoto KI
Biopharm Drug Dispos 35(4):207-217 (2014)

Mechanisms of lower maintenance dose of tacrolimus in obese patients. Sawamoto K, Huong TT, Sugimoto N, Mizutani Y, Sai Y, Miyamoto KI
Drug Metab Phrmacokinet 29(4):341-347 (2014). Aug 25

Salacia reticulata has therapeutic effects on obesity.
Shimada T, Nakayama Y, Harasawa Y, Matsui H, Kobayashi H, Sai Y, Miyamoto KI, Tomatsu S, Aburada M.
J Nat Med 68(4):668-676 (2014). Oct

Long-term follow-up of post hematopoietic stem cell transplantation for Hurler syndrome: clinical, biochemical, and pathological improvements.
Yasuda E, Mackenzie W, Ruhnke K, Shimada T, Mason RW, Zustin J, ThackerM, Orii T, Sai Y, Tomatsu S.
Mol Genet Metab Rep 2:65-76 (2015). Mar

Potent SIRT1 Enzyme-stimulating and Anti-glycation Activities of Polymethoxyflavonoids from Kaempferia parviflora.
Nakata A, Koike Y,Matsui H, Shimada T, Aburada M, Yang J
Natural Product Communications 9 (9):1291-4 (2014). June 1

Establishment of heparan sulfate assay by using automated high-throughput mass spectrometry.
Shimada T, Kelly J, LaMarr WA, Vlies N, Yasuda E, Mason RW, Mackenzie W, Kubaski F, Giugliani R, Chinen Y, Yamaguchi S, Suzuki Y, Orii KE, Fukao T, Orii T, Tomatsu S　
Mol Genet Metab 113:92–99 (2014). May 27

Enzyme replacement therapy in newborn mucopolysaccharidosis IVA mice: early treatment rescues bone lesions? Tomatsu S, Montaño AM, Oikawa H, Dung VC, Hashimoto A, Oguma T, Gutiérrez ML, Takahashi T, Shimada T, Orii T, Sly WS Mol Genet Metab 114:195-202 (2014). May 27

Chondroitin 6-sulfate as a novel biomarker for mucopolysaccharidosis IVA and VII
Shimada T, Tomatsu S, Yasuda E, Maso WR, Mackenzie WG, Shibata Y, Kubaski F, Giugliani R, Yamaguchi S,Suzuk ,Orii K, Orii T.
J Inherit Metab Dis Reports 16:15-24 (2014). May 22

Suppression of adipocyte hypertrophy by polymethoxyflavonoids isolated from Kaempferia parviflora.
Okabe Y, Shimada T, Horikawa T, Kinoshita K, Koyama K, Ichinose K, Aburada M, Takahashi K.
Phytomedicine12:800-6 (2014).May 15

Impact of Enzyme Replacement Therapy and Hematopoietic Stem Cell Therapy on Growth in Patients with Hunter Syndrome.
Patel P, Suzuki Y, Tanaka A, Yabe H, Kato S, ShimadaT, Mason RW, Orii KE, Fukao T, Orii T, Tomatsu S.
Mol Genet Metab Rep 1:184-196 (2014) Apr 1

A dietary restriction influences the progression but not the initiation of MSG-Induced nonalcoholic steatohepatitis.
Fujimoto M, Tsuneyama K, Nakanishi Y, Salunga TL, Nomoto K, Sasaki Y, Iizuka S, Nagata M, Suzuki W, Shimada T, Aburada M, Shimada Y, Gershwin ME, Selmi C.
J Med Food 17(3):374-83 (2014). Mar 17

Assay for glycosaminoglycans by tandem mass spectrometry and its applications.
Tomatsu S, Shimada T, Mason RW, Kelly J, LaMarr WA, Yasuda E, Shibata Y, Futatsumori H, Montaño AM, Yamaguchi S, Suzuki Y, Orii T
J Anal Bioanal Tech 2014 S2: 006. Mar 1 doi:10.4172/2155-9872.S2-006

Enzyme replacement therapy on hypophosphatasia mouse model
Oikawa H, Tomatsu S, Haupt B, Montaño AM, Shimada T, Sly WS,
J Inherit Metab Dis (2014) 37(2):309-17 Mar 1

Growth charts for patients with Hunter syndrome
Patel P, Suzuki Y, Maeda M, Yasuda E, Shimada T, Orii KE, Orii T, Tomatsu S.
Mol Genet Metab 1, 5–18, (2014). Oct 3

Basic fibroblast growth factor is essential to maintain endothelial progenitor cell phenotype in TR-BME2 cells
Sai Y, Nishimura T, Muta M, Iizasa H, Miyata T, Nakashima E.
Biol Pharm Bull 37(4):688-693 (2014). Apr 15

System A amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts.
Nishimura T, Yagi R, Usuda M, Oda K, Yamazaki M, Suda S, Okazaki F, Sai Y, Higuchi K, Maruyama T, Tomi M, Nakashima E.
Biochim Biophys Acta (Biomembrane) 1838(5):1306-1312 (2014). May

Fetal growth retardation and lack of hypotaurine in ezrin knockout mice. Nishimura T, Higuchi K, Sai Y, Sugita Y, Yoshida Y, Tomi M, Wada M, Wakayama T, Tamura A, Tsukita S, Soga T, Nakashima E.
PLoS ONE 21;9(8):e105423 (2014). Aug 21

Glycogen synthase kinase 3β sustains invasion of glioblastoma via the focal adhesion kinase, Rac1 and c-Jun N-terminal kinase-mediated pathway
Chikano Y, Domoto T, Furuta T, Sabit H, Kitano-Tamura A, Pyko IV, Takino T, Sai Y, Hayashi Y, Sato H, Miyamoto K, Nakada M, Minamoto T.
Mol Cancer Ther Feb;14(2):564-574 (2015). Feb

がん化学療法施行患者における客観的な指標を用いた嗅覚異常の評価
菅　幸生、川岸篤史、石崎純子、竹田和喜、原　祐輔、崔　吉道、志賀英明、宮本謙一．
日本病院薬剤師会雑誌 50(6):745-748 (2014). Jun

無包装状態における経口製剤の安定性の検討．
井戸田陽子、萩原健弘、齊藤早知、板井進悟、崔　吉道、荻原琢男．
医療薬学 40(5):304-309 (2014). May

南　哲弥、眞田順一郎、小林　聡、香田　渉、蒲田敏文、荒井邦明、山下達也、金子 周一、原　祐輔、竹田和喜、崔　吉道、松井　修(2014)金沢大学附属病院でのディーシービーズの使用方法 映像情報MEDICAL 46(8):754-758. Aug

75g 経口ブドウ糖負荷試験から見た反応性低血糖発現における危険因子の検討．
岡田守弘、岡田昌江、西上　潤、渡辺和良、崔　吉道．
日本病院薬剤師会雑誌 50(11):1329-1332 (2014). Nov

2013年度 (#294-311)

Influence of long-term enteral nutrition on pharmacokinetics of digoxin in rats.
Higashi K, Tanaka C, Imanishi K, Sawamoto K, Horikawa T, Ohkawa H, Matsushita R, Sai Y, Miyamoto KI
Drug Metab. Pharmacokin 28(1), 44-52 (2013)

Ligand-dependent EphB1 signaling suppresses glioma invasion and correlates with patient survival.
Teng L, Nakada M, Furuyama N, Sabit H, Furuta T, Hayashi Y, Takino T, Dong Y, Sato H, Sai Y, Miyamoto K, Berens ME, Zhao SG, Hamada
J.Neuro Oncol. 2013 Dec;15(12):1710-20.

Incidence of injection site reactions induced by vinorelbine and prevention with hot compresses. Makoto Hayashi,Chie Ohnishi, Hayato Sugimura, Keniji Miyazawa, Akimasa Yamatani, Hiromu Funaki, Kenichi Miyamoto Jpn. J. Drug Inform., 15 (1), 8-12 (2013)

Aberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therapy Ayako Kitano,Takeo Shimasaki, Yuri Chikano, Mitsutoshi Nakada, Mayumi Hirose, Tomomi Higashi, Yasuhito Ishigaki, Yoshio Endo, Takahisa Takino, Hiroshi Sato, Yoshimichi Sai,Ken-ichi Miyamoto, Yoshiharu Motoo, Kazuyuki Kawakami, Toshinari Minamoto PLoS

One.2013;8(2):e55289. doi: 10.1371/journal.pone.0055289. Epub 2013 Feb 8
Involvement of carnitine/organic cation transporter OCTN1/SLC22A4 in gastrointestinal absorption of metformin.
Nakamichi N, Shima H, Asano S, Ishimoto T, Sugiura T, Matsubara K, Kusuhara H, Sugiyama Y, Sai Y, Miyamoto KI, Tsuji A, Kato Y.
J Pharm Sci 102(9):3407-3417 (2013). Sep


Estrogen receptor α induction by mitoxantrone increases Abcg2 expression in placental trophoblast cells.
Oda K, Nishimura T, Higuchi K, Ishido N, Ochi K, Iizasa H, Sai Y, Tomi M, Nakashima E.
J Pharm Sci 102(9):3364-3372 (2013). Sep


Evaluation of rat in vivo fetal-to-maternal transfer clearances of various xenobiotics by umbilical perfusion.
Nishimura T, Takanohashi T, Tomi M, Horikoshi M, Higuchi K, Sai Y, Nakashima E.
J Pharm Sci 102(9):3356-3363 (2013). Sep


Hepatic arterial infusion chemotherapy with gemcitabine and 5‑fluorouracil or oral S‑1 improves the prognosis of patients with postoperative liver metastases from pancreatic cancer.
Hidehiro Tajima, Hirohisa Kitagawa, Tomoya Tsukada, Koichi Okamoto, Shin‑Ichi Nakanuma, Seisho Sakai, Isamu Makino, Hiroyuki Furukawa, Hironori Hayashi, Katsunobu Oyama, Masafumi Inokuchi, Hisatoshi Nakagawara, Tomoharu Miyashita, Hiroshi Itoh, Hideto Fujita, Hiroyuki Takamura, Itasu Ninomiya, Sachio Fushida, Takashi Fujimura, Tetsuo Ohta, Wataru Koda, Tetsuya Minami, Yasuji Ryu, Junichiro Sanada, Toshifumi Gabata, Osamu Matsui, Yoshimichi Sai
Mol Clin Oncol 1(5):869-874 (2013). Sep


Integrin α3 is overexpressed in glioma stem-like cells and promotes invasion.
Nakada M, Nambu E, Furuyama N, Yoshida Y, Takino T, Hayashi Y, Sato H, Sai Y, Tsuji T, Miyamoto KI, Hirao A, Hamada JI.
Br J Cancer 108(12):2516-2524 (2013). Jun 25


Pathogenesis of Morquio A syndrome: An autopsied case reveals systemic storage disorder,
Yasuda E, Fushimi K, Suzuki Y, Shimizu K, Takami T, Zustin J, Patel P, Ruhnke K, Shimada T, Boyce B, Kokas T, Barone C, Theroux M, Mackenzie W, Nagel B, Ryerse JS., Orii KE, Iida H, Orii T, Tomatsu S
Mol Genet Metab, 109: 301–311(2013).

Spontaneous onset of nonalcoholic steatohepatitis and hepatocellular carcinoma in a mouse model of metabolic syndrome.
Nishida T, Tsuneyama K, Fujimoto M, Nomoto K, Hayashi S, Miwa S, Nakajima T, Nakanishi Y, Sasaki Y, Suzuki W, Iizuka S, Nagata M, Shimada T, Aburada M, Shimada Y, Imura J.
Lab Invest. 93:230-41 (2013).

Aging-like skin changes in metabolic syndrome model mice are mediated by mineralocorticoid receptor signaling.
Nagase T, Akase T, Sanada H, Minematsu T, Ibuki A, Huang L, Asada M, Yoshimura K, Nagase M, Shimada T, Aburada M, Nakagami G, Sugama J.
Aging Cell. 12:50-7 (2013).

Hepatic arterial infusion chemotherapy with gemcitabine for patients with postoperative liver metastases from pancreatic cancer]. Tajima H, Kitagawa H, Shoji M, Okamoto K, Nakanuma S, Sakai S, Kinoshita J, Makino I, Hayashi H, Nakamura K, Oyama K, Nakagawara H, Miyashita T, Takamura H, Ohta T, Minami T, Koda W, Sanada J, Gabata T, Sai Y. Gan To Kagaku Ryoho. 2013 Nov;40(12):1668-71.

エピルビシン塩酸塩の投与時間短縮およびフラッシュの追加による静脈炎の予防効果の改善
磯田和也、菅　幸生、竹田和喜、原　祐輔、大川浩子、西上　潤、古河浩之、井口雅史、崔　吉道、宮本謙一
医療薬学、39 (11), 644-649 (2013)

2012年度 (#280-293)

Aberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therap.
Ayako Kitano, Takeo Shimasaki, Yuri Chikano, Mitsutoshi Nakada, Mayumi Hirose, Tomomi Higashi, Yasuhito Ishigaki, Yoshio Endo, Takahisa Takino, Hiroshi Sato, Yoshimichi Sai, Ken-ichi Miyamoto, Yoshiharu Motoo, Kazuyuki Kawakami, Toshinari Minamoto .
PLoS One.8(2):e55289 (2013). Feb, doi: 10.1371/journal.pone.0055289


Puerariae floｓ alleviates metabolic diseases in Western diet-loaded spontaneously obese type 2 diabetic model mice.
Koshi Kubo, Tsutomu Shimada, Rei Onishi, Masahito Tsubata, Tomoyasu Kamiya, Rika Nagamine, Seiichi Iizuka, Yoshimichi Sai, Sakae Amagaya, MasakiAburada, Ken-ichi Miyamoto
J. Natural Med. 66(4):622-630 (2012). Oct


Metformin prevents and reverses the pathological development in a non-diabetic mouse model of nonalcoholic steatohepatitis.
Yuki Kita , Toshinari Takamura, Hirofumi Misu, Tsuguhito Ota, Seiichiro Kurita, Masafumi Uno, Naoto Matsuzawa-Nagata, Hitoshi Ando, Akio Fujimura, Kouji Hayashi, Toru Kimura, Ken-ichi Miyamoto, Yoh Zen, Yasuni Nakanuma, Shuichi Kaneko
PLoS One 7(9):e43056 (2012). Sep


Mechanism of nucleoside uptake in rat placenta and induction of placental CNT2 in experimental diabetes.
Nishimura Tomohiro, Chishu Takuya, Tomi Masatoshi, Nakamura Ryo, Sato Kazuko, Kose Noriko, Sai Yoshimichi, Nakashima Emi.
Drug Metab. Pharmacokinet. 27(4):439-446 (2012). Aug


Relationship between bathing habits and physical and psychological state.
Taichi Ishizawa, Satoshi Watanabe, Shingo Yano, Masaki Aburada, Ken-ichi Miyamoto, Toshiyuki Ojima, Shinya Hayasaka
J. Jpn. Soc. Balneol. Climatol. Phys. Med. （日温気物医志） 75(4):227-236 (2012) . Aug


Pharmacist-based donepezil outpatient consultation service to improve medication persistence.
Norio Watanabe, Keiko Yamamura, Yusuke Suzuki, Katsuro Shigeno, Ryo Matsushita, Yoshimichi Sai, Ken-ichi Miyamoto, Kiyofumi Yamada
Patient Prefer. Adherence 6:605-611 (2012). Aug


CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status.
Hironori Kitade, Kazuki Sawamoto, Mayumi Nagashimada, Hiroshi Inoue, Yasuhiko Yamamoto, Yoshimichi Sai, Toshinari Takamura, Hiroshi Yamamoto, Ken-ichi Miyamoto, Henry N. Ginsberg, Naofumi Mukaida, Shuichi Kaneko, Tsuguhito Ota
Diabetes 61(7):1680-1690 (2012). Jul


非定型抗精神病薬処方時の耐糖能フォローアップの調査結果
坪内清貴，田平裕美子，増江俊子，菅　幸生，小柴美紀恵，前田大蔵，長澤達也，篁　俊成，三邉義雄，崔　吉道，宮本謙一
精神医学 54(7):681-688 (2012) . Jul


Change in pharmacokinetics of mycophenolic acid as a function of age in rats and effect of coadministered amoxicillin/clavulanate.
Junko Ishizaki, Tomoko Tsuda, Yukio Suga, Satsuki Ito, Kunizo Arai, Yoshimichi Sai, Ken-ichi Miyamoto
Biol. Pharm. Bull. 35(7):1009-1013 (2012) . Jul


Chatelut式でカルボプラチン投与量を算出したTC療法による血小板減少の危険因子の解析
廣正　瑛，菅　幸生，高林真貴子，大川浩子，崔　吉道，京　哲，宮本謙一
日病薬誌 48(6):731-734 (2012) . Jun


Elimination of teicoplanin by adsorption to the filter membrane during haemodiafiltration: screening experiments for linezolid, teicoplanin and vancomycin followed by in vitro haemodiafiltration models for teicoplanin.
Yosuke Shiraishi, Masaki Okajima, Yoshimichi Sai, Ken-ichi Miyamoto, Hideo Inaba
Anaesth Intensive Care 40(3):442-449 (2012). May


Polymethoxyflavonoids from Kaempferia parviflora induce adipogenesis on 3T3-L1 preadipocytes by regulating transcription factors at an early stage of differentiation.
Takumi Horikawa, Tsutomu Shimada, Yui Okabe, Kaoru Kinoshita, Kiyotaka Koyama, Ken-ichi Miyamoto, Koji Ichinose, Kunio Takahashi, Masaki Aburada
Biol. Pharm. Bull. 35(5):686-692 (2012). May


パクリタキセル注射薬後発医薬品の安全性評価
築山郁人、堀田、竹内、大西、富山、斉藤寛子、崔　吉道、宮本謙一、長谷川高明
癌と化学療法 39(4):613-617 (2012) . Apr

2011年度 (#264-279)

Enhanced renal clearance of vancomycin in rats with carcinogen-induced osteosarcoma.
Izumi Shimada, Chieko Iwata, Shino Taga, Hitomi Teramachi, Masaaki Nomura, Ken-ichi Miyamoto, Hiroyuki Tsuchiya, Takashi Wada, Kazuko Kimura, Ryo Matsushita
Anticancer Res. 32(3):823-829 (2012). Mar


Flavangenol (pine bark extract) and its major component procyanidin B1 enhance fatty acid oxidation in fat-loaded models.
Tsutomu Shimada, Daisuke Tokuhara, Masahito Tsubata, Tomoyasu Kamiya, Mayu Kamiya (Sameshima), Rika Nagamine, Kinya Takagaki, Yoshimichi Sai, Ken-ichi Miyamoto, Masaki Aburada
Eur. J. Pharmacol. 677(1-3): 147-153 (2012). Feb


塩酸ゲムシタビンの経静脈投与による血管痛の危険因子の解析とNSAIDs・オピオイドによる予防効果の評価
菅　幸生，坂口百合野，石﨑純子，高林真貴子，橋本千明，廣正　瑛，日沖雅人，崔　吉道，荒井國三，宮本謙一
医療薬学, 38(3):177-183 (2012). Feb


Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation.
Kumi Kimura, Tomoko Yamada, Shuichi Kaneko, Michihiro Matusmoto, Yoshiaki Kido, Tetsuya Hosooka, Shun-ichiro Asahara, T. Matsuda, Tsuguhito Ota, Hiroshi Watanabe, Yoshimichi Sai, Ken-ichi Miyamoto, Masato Kasuga, Hiroshi Inoue
Diabetes 61(): 61-73 (2012). Jan


De-alcoholization of paclitaxel injection for clinical application.
Ikuto Tsukiyama, Masayuki Takeuchi, Fumie Abe, Takahiko Kisi, Hiroko Saito, Yukihiko Obayashi, Kazushi Watanabe, Akihiko Wakatsuki, Ken-ichi Miyamoto, Takaaki Hasegawa
Anticancer Res. 31(12): 4339-4346 (2011). Dec


がん化学療法による味覚障害と嗅覚障害に関する実態調査
菅 幸生，北出紘規，川岸篤史，竹田和喜，春木一伸，石﨑純子，崔 吉道，笠原寿郎，荒井國三，宮本謙一
癌と化学療法, 38: 2617-2621 (2011). Dec


mTORC1 activation triggers the unfolded protein response in podocytes and leads to nephrotic syndrome
Noriko Ito, Yukino Nishibori, Ito Yugo, Hisashi Takagi, Yoshihiro Akimoto, Akihiko Kudo, Katsuhiko Asanuma, Yoshimichi Sai, Ken-ichi Miyamoto, Hitoshi Takenaka, and Kunimasa Yan
Lab. Invest. 91:1584-1594 (2011). Nov


Preventive effect of geniposide on metabolic disease status in spontaneously obese type 2 diabetic TSOD mice and free fatty acid-treated HepG2 cells.
Kazuko Kojima, Tsutomu Shimada, Yasuhiro Nagareda, Michiru Watanabe, Junko Ishizaki, Yoshimichi Sai, Ken-ichi Miyamoto, Masaki Aburada
Biol. Pharm. Bull. 34(10), 1613-1618 (2011). Oct


食道癌の化学放射線療法に合併した食道炎の痛みに対してPCAによるフェンタニル投与が有用であった1症例．
山田圭輔，松久大希，武川治水，山本　健，原　祐輔
ペインクリニック，32 (10), 1577-157 (2011). Oct


医薬品添付文書中の薬物動態パラメータの研究(3)　―ジェネリック医薬品の生物学的同等性試験における薬物動態パラメータの試験間および試験内変動の解析―.
小玉菜央，金本理沙，叶　隆，岡田裕子，森本かおり，崔　吉道，荻原琢男
医療薬学, 37(9), 543-550 (2011). Sep


Enhancement of zidovudine transfer to Molt-4 cells, a human T cell model, by dehydroepiandrosterone sulfate
Tomohiro Nishimura, Jun Tanaka, Masatoshi Tomi, Yoshiaki Seki, Noriko Kose, Yoshimichi Sai, Emi Nakashima
J Pharm Sci 100(9):3959-3967(2011). Sep


A randomized, quadruple crossover single-blind study on immediate action of chewed and unchewed low-dose acetylsalicylic acid tablet in healthy volunteers.
Yoshimihichi Sai, Akiyo Kusaka, Kaori Imanishi, Manami Matsumoto, Rie Takahashi, Natsumi Sugimoto, Takako Anada, Hidesaku Asakura, Ken-ichi Miyamoto
J. Pharm. Sci. 100(9):3884-3891(2011). Sep


6-Mercaptopurine transport by equilibrative nucleoside transporters in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBTs
Na-Young Lee, Yoshimichi Sai, Emi Nakashima, Sumio Ohtsuki, Tetsuya Terasaki, Young-Sook Kang
J Pharm Sci 100(9):3773-3782 (2011). Sep


Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis.
Ryota Kurayama, Noritko Ito, Yukino Nishibori, Daisuke Fukuhara, Yoshihiro Akimoto, Eiji Higashihara, Yasuhito Ishigaki, Yoshimichi Sai, Ken-ichi Miyamoto, Hitoshi Endou, Yoshikatsu Kanai, Kunimasa Yan
Lab. Invest., 91:992-1006 (2011). Jul


Salacia reticulata inhibits differentiation of 3T3-L1 adipocytes.
Tsutomu Shimada, E Nagai, Y Harasawa, M Watanabe, K Negishi, T Akase, Yoshimichi Sai, Ken-ichi Miyamoto, Masaki Aburada
J. Ethnopharmacol. 136 67-74 (2011). Jun


Byakkokaninjinto prevents body water loss by increasing the expression of kidney aquaporin-2 and skin aquaporin-3 in KKAy mice.
Takashi Aburada, Nobutomo Ikarashi, Mai Kagami, Yuhei Ichikawa, Megumi Sugitani, Ayaka Maniwa, Harumi Ueda, Takahiro Toda, Kiyomi Ito, Wataru Ochiai, Ryo Matsushita, Ken-ichi Miyamoto, Kiyoshi Sugiyama
Phytother. Res., 25(6):897-903DOI:10.1002/ (2011). Jun


Preventive effects of Salacia reticulata on non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) in monosodium glutamate treated mice.
Michiru Watanabe, Tsutomu Shimada, Seiichi Iiduka, Nanae Iida, Kazuko Kojima, Junko Ishizaki, Yoshimichi Sai, Ken-ichi Miyamoto, Masaaki Aburada
J. Trad. Med., 28(2) 73-82 (2011). May

2010年度 (#252-263)

Preventive effect of pine bark extract (flavangenol) on metabolic disease in Western diet-loaded TSOD mice.
Tsutomu Shimada, Mitsutaka Kosugi, Daisuke Tokuhara, Masahito Tsubata, Tomoyasu Kamiya, Mayu Sameshima, Roka Nagamine, Kinya Takagaki, Ken-ichi Miyamoto, Masaki Aburada
Evidence Based Complementary and Alternative Medicine, 185913 doi:10.1093/ecam/nep231 (2011). Mar


Clustering analysis of Keishibukuryogan formulas by use of self-organizing maps.
Hisanori Satomi, Yoshikazu Mori, Bunshou Makino, Youichirou Nakai, Shuuichi Takeda, Masaki Aburada, Ken-ichi Miyamoto
Chem. Pharm. Bull., 58(11), 1497-1501 (2010). Nov


Protecting cisplatin-induced nephrotoxicity with cimetidine does not affect antitumor activity.
Hiromu Katsuda, Mariko Yamashita, Hideyuki Katsura, Jia Yu, Yoshihiro Waki, Naoto Nagata , Yoshimichi Sai, Ken-ichi Miyamoto
Biol. Pharm. Bull., 33(11), 1867-1871 (2010). Nov


A liver-derived secretory protein, selenoprotein P, causes insulin resistance.
Hirofumi Misu, Toshinari Takamura, Hiroaki Takayama， Hiroto Hayashi, Naoto Matsuzawa-Nagata, Seiichiro Kurita, Kazuhide Ishikura, Hitoshi Ando, Yumie Takeshita, Tsuguhito Ota, Masaru Sakurai, Tatsuya Yamashita, Eishiro Mizukoshi, Taro Yamashita, Masao Honda, Ken-ichi Miyamoto, Tetsuya Kubota, Naoto Kubota, Takashi Kadowaki, Han-Jong Kim, In-kyu Lee, Yasuhiko Minokoshi, Yoshiro Saito, Kazuhiko Takahashi, Yoshihiro Yamada, Nobuyuki Takakura, Shuichi Kaneko
Cell Metabolism, 12, 483-495 (2010). Nov


Roles of TauT and system A in cytoprotection of rat syncytiotrophoblast cell line exposed to hypertonic stress.
Tomohiro Nishimura, Yoshimichi Sai, Jo Fujii, Mariko Muta, Hisashi Iizasa, Masatoshi Tomi, Noriko Kose, Emi Nakashima
Placenta, 31(11), 1003-1009 (2010). Nov


Proton-coupled erythromycin antiport at rat blood-placenta barrier.
Yoshimichi Sai, Tomohiro Nishimura, Kaori Ochi, Noriaki Tanaka, Akinori Takagi, Masatoshi Tomi, Noriko Kose, Yasuna Kobayashi, Naoki Miyakoshi, Shinji Kitagaki, Chisato Mukai, Emi Nakashima
Drug. Metab. Dispos., 38(9), 1576-1581 (2010). Sep


Differential expression of ezrin and CLP36 in the two layers of syncytiotrophoblast in rats.
Kei Higuchi, Hisashi Iizasa, Yoshimichi Sai, Satomi Horieya, Kyeong-Eun Lee, Masami Wada, Masayuki Deguchi, Tomohiro Nishimura, Tomohiko Wakayama, Atsushi Tamura, Sachiko Tsukita, Noriko Kose, Young-Sook Kang, Emi Nakashima
Biol. Pharm. Bull., 33(8), 1400-1406 (2010). Aug


Pharmacokinetics of [6]-Shogaol, a Pungent Ingredient of Zingiber officinale Roscoe (Part I).
Akitoshi Asami, Tsutomu Shimada, Yasuharu Mizuhara, Takayuki Asano, Shuichi Takeda, Takashi Aburada, Ken-ichi Miyamoto, Masaki Aburada
J. Nat. Med., 64 (3), 281-287 (2010). Jul


Metabolic disease prevention and suppression of fat accumulation by salacia reticulate.
Tsutomu Shimada, Eiichi Nagai, Yukiko Harasawa, Takashi Aburada, Seiichi Iizuka, Ken-ichi Miyamoto, Masaki Aburada
J. Nat. Med., 64 (3), 266-274 (2010). Jul


石川県病院薬剤師の業務活動状況：日本病院薬剤師会による全国調査との比較
宮本謙一、森　正昭、上田和男、西尾浩次
日本病院薬剤師会誌、46 (5), 679-683 (2010). May


Effects of paddle-shaft position and inclination of dissolution apparatus on the dissolution rate of carbamazepine tablets and the equivalence assessment of generic drugs.
Mari Fujimoto, Kiyoshi Mihara, James A. Jorgenson, Kuniko Otsuka, Masaki Aburada , Tomie Kawada, Junko Ishizaki, Ken-ichi Miyamoto, Makoto Otsuka
Dissolution Technologies, 17, 36-44 (2010). May


小児と成人におけるボリコナゾールの血中濃度解析の比較　
伊藤さつき，石﨑純子，小柴美紀恵，五十嵐康郎，長田直人，菅　幸生，西村良成，前馬秀明，小泉晶一，中尾眞二，横川弘一，崔　吉道，宮本謙一
医療薬学，36(4), 213-219 (2010). Apr

2009年度 (#239-251)

Metabolic disease prevention and suppression of fat accumulation by salacia reticulate.
Tsutomu Shimada, Eiichi Nagai, Yukiko Harasawa, Takashi Aburada, Seiichi Iizuka, Ken-ichi Miyamoto, Masaki Aburada
J. Nat. Med., 64(3), 266-274 (2010). Mar

Surfactants influence the distribution of taxanes in peritoneal dissemination tumor-bearing rats.
Yukio Kamijo, Chie Ito, Masaaki Nomura, Yoshimichi Sai, Ken-ichi Miyamoto
Cancer Lett., 287(2), 182-186 (2010). Jan

Evaluation of selective competitive binding of basic drugs to α1-acid glycoprotein variants.
Junko Ishizaki, Akiko Hukaishi, Chie Fukuwa, Satoko Yamazaki, Mayu Tabata, Takuya Ishida, Yukio Suga, Kunizo Arai, Koichi Yokogawa, Ken-ichi Miyamoto
Biol. Pharm. Bull., 33 (1), 95-99 (2010). Jan

外来化学療法における嗅覚の変化
志賀英明、川岸篤史、宮本謙一、笠原寿郎、三輪高喜
日本味と匂学会誌、16(3), 653-654 (2009)

Effects of the position of the paddle shaft on the dissolution rates of sodium diclofenac tablets and the equivalence assessment of the generic product.
Mari Fujimoto, Kiyoshi Mihara, James A. Jorgenson, Kuniko Otsuka, Masaki Aburada, Tomie Kawada, Junko Ishizaki, Ken-ichi Miyamoto, Makoto Otsuka
Dissolution Technologies, 16(4), 29-34 (2009). Nov

Wilms’ tumor 1 (WT1) peptide immunotherapy for gynecological malignancy.
Satoshi Ohno, Satoru Kyo, Subaru Myojo, Satoshi Dohi, Junko Ishizaki, Ken-ichi Miyamoto, Satoshi Morita, Jun-ichi Sakamoto, Katayuki Enomoto, Tadashi Kimura, Yoshihiro Oka, Akihiro Tsuboi, Haruo Sugiyama, Masaki Inoue
Anticancer Res., 29(11), 4779-4784 (2009). Nov

Effect of low-dose paclitaxel and docetaxel on endothelial progenitor cell.
Mariko Muta, Tomonori Yanagawa, Yoshimichi Sai, Shigehira Saji, Eiji Suzuki, Tomoyuki Aruga, Katsumasa Kuroi, Gaku Matsumoto, Masakazu Toi, Emi Nakashima.
Oncology 77(3-4), 182-191 (2009). Sep

Dose dependent development of diabetes mellitus and non-alcoholic steatohepatitis in monosodium glutamate-induced obese mice.
Yoshiyuki Sasaki, Wataru Suzuki, Tsutomu Shimada, Seiichi Iizuka, Satoko Nakamura, Mitsunobu Nagata, Makoto Fujimoto, Koichi Tsuneyama, Ryoji Hokao, Ken-ichi Miyamoto, Masaki Aburada
Life Sci., 85 (13-14), 490-498 (2009). Sep

Effect of betamethasone phosphate loaded polymeric nanoparticles on a murine asthma model.
Yukiko Matsuo, Tsutomu Ishihara, Junko Ishizaki, Ken-ichi Miyamoto, Megumu Higaki, Naomi Yamashita
Cell. Immun., 260(1), 33-38 (2009). Aug

Impact of serum caffeine monitoring on adverse effects and chemotherapeutic responses to caffeine-potentiated chemotherapy for osteosarcoma.
Katsuhiro Hayashi, Hiroyuki Tsuchiya, Norio Yamamoto, Toshiharu Shirai, Kensuke Yamauchi, Akihiro Takeuchi, Masami Kawahara, Ken-ichi Miyamoto, Katsuro Tomita
J. Orthop. Sci., 14, 253-258 (2009). May

Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria.
Seiji Nakamura, Toshinari Takamura, Naoto Matsuzawa-Nagata, Hirofumi Misu, Hiroyo Noda, Satoko Nabemoto, Seiichiro Kurita, Hitoshi Ando, Ken-ichi Miyamoto, Shuichi Kaneko
J. Biol. Chem., 284(22), 14809-14818 (2009). May

Effect of β-phenylethylamine on extracellular concentration of dopamine in the nucleus accumubens and prefrontal cortex.
Mikio Murata, Nobuyuki Katagiri, Kota Ishida, Kenji Abe, Masago Ishikawa, Iku Utsunomiya, Ken-ichi Miyamoto, Kyoji Taguchi
Brain Res., 1269, 40-46 (2009). May

Expression, localization and binding activity of the ezrin/radixin/moesin proteins in the mouse testis.
Tomohiko Wakayama, Hiroki Nakata, Miho Kurobo, Yoshimichi Sai, Shoichi Iseki.
J. Histochem. Cytochem., 57(4), 351-362 (2009). Apr

2008年度 (#209-238)

Influx mechanism of 2’, 3’-dideoxyinosine (ddI) and uridine at the blood-placenta barrier.
Kazuko Sato, Yoshimichi Sai, Tomohiro Nishimura, Takuya Chishu, Noriko Kose, Emi Nakashima
Placenta, 30(3), 263-269 (2009). Mar

Urinary excretion of 3-phenoxybenzoic acid in middle-aged and elderly general population of Japan.
Jun Ueyama, Akiko Kimata, Michihiro Kamijima, Nobuyuki Hamajima, Yoshinori Ito, Koji Suzuki, Takashi Inoue, Kanami Yamamoto, Kenji Takagi, Isao Saito, Ken-ichi Miyamoto, Takaaki Hasegawa, Takaaki Kondo
Environ. Res., 109(2), 175-80 (2009). Feb

シスプラチン化学療法における吃逆の危険因子に関する検討
林　誠、杉村勇人、菅　幸生、河原昌美、相宮光二、宮本謙一
医療薬学, 35(2), 89-95 (2009). Feb

エピルビシン液体製剤から凍結乾燥製剤への変更による静脈炎軽減効果の検討
菅　幸生、熊崎雅史、西上　潤、竹田和喜、川岸篤史、石﨑純子、井口雅史、宮本謙一、荒井國三
癌と化学療法, 36(1), 93-96 (2009). Jan

Bone targeting of quinolones conjugated with an acidic oligopeptide.
Tatsuo Takahashi, Koichi Yokogawa, Naoki Sakura, Masaaki Nomura, Shinjiro Kobayashi, Ken-ichi Miyamoto
Pharm. Res., 25(12), 2881-2888 (2008). Dec

Obesity Upregulates Genes Involved in Oxidative Phosphorylation in Livers of Diabetic Patients.
Takamura T, Misu H, Matsuzawa-Nagata N, Sakurai M, Ota T, Shimizu A, Kurita S, Takeshita Y, Ando H, Honda M, Kaneko S.
Obesity , 16(12), 2601-2609 (2008). Dec

製造販売後調査における調査票の現状と標準化の提案
高月公博、古川裕之、松嶋由紀子、宮本謙一
医療薬学, 34(12), 1105-1112 (2008)

Enhancement of zidovudine uptake by dehydroepiandrosterone sulfate in rat syncytiotrophoblast cell line TR-TBT 18d-1
Tomohiro Nishimura, Yoshiaki Seki, Kazuko Sato, Takuya Chishu, Noriko Kose, Tetsuya Terasaki, Young-Sook Kang, Yoshimichi Sai, Emi Nakashima
Drug Metab. Dispos. 36(10), 2080-2085 (2008). Oct

個別症例安全性報告の因果関係評価基準の問題点
高月公博、古川裕之、宮本謙一
医療薬学, 34(9), 838-846 (2008).

Effect of the organophosphorus pesticide diazinon on glucose tolerance in type 2 diabetic rats.
Jun Ueyama, Michihiro Kamijima, Kazumi Asai, Aiko Mochizuki, Dong Wang, Takaai Kondo, Toshiaki Suzuki, Kenji Takagi, Kenzo Takagi, Hiroaki Kanazawa, Ken-ichi Miyamoto, Shinya Wakusawa, Takaaki Hasegawa.
Toxicol Lett., 182(1-3), 42-47 (2008) . Aug

Effect of thalidomide on endotoxin-induced decreases in activity and expression of hepatic cytochrome P4503A2
Jun Ueyama, Masayuki Nadai, Ying Lan Zhao, Hiroaki Kanazawa, Kenji Takagi, Takaaki Kondo, Kenzo Takagi, Shinya Wakusawa, Fumie Abe, Hiroko Saito, Ken-ichi Miyamoto, Takaaki Hasegawa
Biol. Pharm. Bull., 31(8), 1596-1600 (2008). Aug

Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity.
Naoto Matsuzawa-Nagata, Toshinari Takamura, Hitoshi Ando, Seiji Nakamura, Seiichiro Kurita, Hirofumi Misu, Tsuguhito Ota, Masayoshi Yokoyama, Masao Honda, Ken-ichi Miyamoto, Shuichi Kaneko
Metabolism, 57, 1071-1077 (2008). Aug

Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells.
Masaaki Nomura, Tatsuo Takahashi, Naoto Nagata, Kikue Tsutsumi, Shinjiro Kobayashi, Tetsuo Akiba, Koichi Yokogawa, Shuzo Moritani, Ken-ichi Miyamoto
Biol. Pharm. Bull., 31(7), 1403-1409 (2008). Jul

Characterization of the mechanism of Zidovudine uptake by rat conditionally immortalized syncytiotrophoblast cell line TR-TBT
Yoshimichi Sai, Tomohiro Nishimura, Sarin Shimpo, Takuya Chishu, Kazuko Sato, Noriko Kose, Tetsuya Terasaki, Chiaki Mukai, Naoki Miyakoshi, Young-Sook Kang, Emi Nakashima
Pharm. Res. 25(7), 1647-1653 (2008). Jul

Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis.
Masafumi Uno, Seiichiro Kurita, Hirofumi Misu, Hitoshi Ando, Tsuguhito Ota, Naoto Matsuzawa-Nagata, Yuki Kita, Satoko Nabemoto, Hiroshi Akahori, Yoh Zen, Yasuni Nakanuma, Shuichi Kaneko, Toshinari Takamura
Hepatology, 48(1), 109-118 (2008). Jul

Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects.
Seiichiro Kurita, Toshinari Takamura, Tsuguhito Ota, Naoto Matsunaga-Nagata, Yuki Kita, Masafumi Uno, Satoko Nabemoto, Kazuhide Ishikura, Hirofumi Misu, Hitoshi Ando, Yoh Zen, Yasuni Nakanuma, Shinichi Kaneko
Eur. J. Pharmacol., 588(2-3), 316-324 (2008). Jul

Supplementation of fat emulsion improves fatty liver caused by receiving total-parenteral nutrition in young adult rats.
Hiroko Ohkawa, Chie Fukuwa, Naoto Matsuzawa-Nagata, Koichi Yokogawa, Kenji Omura, Ken-ichi Miyamoto
Jpn. J. Pharm. Health Care Sci., 34(7), 630-637 (2008). Jul

Inhibitory effects of caffeine analogues on neoplastic transformation: Structure-activity relationship.
Evgeny A. Rogozin, Ki Won Lee, Masaaki Nomura, Ken-ichi Miyamoto, Haoyu Yu, Allan H. Conney, Ann M. Bode, Zigang Dong
Carcinogenesis, 29(6), 1228-1234 (2008). Jun

Acidic amino acid tag enhances response to enzyme replacement in mucopolysaccharidosis type VII mice.
AM Montano, H Oikawa, S Tomatsu, T Nishioka, C Vogler, MA Gutierres, T Oguma, Y Tan, JH Grubb, VC Dung, A Ohashi, KI Miyamoto, T Orii, Y Yoneda, WS Sly
Mol. Genet. Metab., 94(2), 178-189 (2008). Jun

Involvement of carnitine/organic cation transporter OCTN2 (SLC22A5) in distribution of its substrate carnitine to the heart
Daisuke Iwata, Yukio Kato, Tomohiko Wakayama, Yoshimichi Sai, Yoshiyuki Kubo, Shoichi Iseki, Akira Tsuji
Drug Metab. Pharmacokinet. 23(3), 207-215 (2008). Jun

Involvement of multidrug resistance-associated protein 2 (Abcc2) in molecular weight-dependent biliary excretion of (beta)-lactam antibiotics
Yukio Kato, Seiko Takahara, Sayaka Kato, Yoshiyuki Kubo, Yoshimichi Sai, Ikumi Tamai, Hikaru Yabuuchi, Akira Tsuji
Drug Metab. Dispos. 36(6), 1088-1096 (2008). Jun

Caffeine dose-dependently potentiates the anti-tumor effect of cisplatin on osteosarcomas.
Masami Kawahara, Yuri Takahashi, Koichi Yokogawa, Kotaro Takazawa, Hiroyuki Tsuchiya, Katsuo Tomita, Ken-ichi Miyamoto
Anticancer Res., 28, 1681-1686 (2008). May-Jun

The antitumor effect of liposome-encapsulated cisplatin on rat osteosarcoma and its　enhancement by caffeine.
Michiaki Karita, Hiroyuki Tsuchiya, Masami Kawahara, S. Kasaoka, Katsuro Tomita
Anticancer Res., 28(3A), 1449-1457 (2008). May-Jun

Mechanism of decrease of oral bioavailability of cyclosporine A during immunotherapy upon coadministration of amphotericin B.
Junko Ishizaki, Satsuki Ito, Mingji Jin, Tsutomu Shimada, Tamae Ishigaki, Yukiko Harasawa, Koichi Yokogawa, Akiyoshi Takami, Shinji Nakao, Ken-ichi Miyamoto
Biopharm. Drug Dispos., 29, 195-203 (2008). May

Structure activity relationships of quinoxaline-2-one derivatives as platelet-derived growth factor-b receptor (PDGF-R) inhibitors, derived from molecular modeling.
Yoshikazu Mori, Takatsugu Hirokawa, Katsuyuki Aoki, Hisanori Satomi, Shuichi Takeda, Masaki Aburada, Ken-ichi Miyamoto
Chem. Pharm. Bull., 56(5), 682-687 (2008). May

Potential of various drugs to inhibit nucleoside uptake in rat syncytiotrophoblast cell line, TR-TBT 18d-1
Takuya Chishu, Yoshimichi Sai Y, Tomohiro Nishimura, Kazuko Sato, Noriko Kose, Emi Nakashima
Placenta, 29(5), 461-467 (2008). May

Soybean fat supplentation controls insuline resistance caused by fat-free parenteral nutrition.
Hiroko Ohkawa, Chie Fukuwa, Naoto Matsuzawa-Nagata, Koichi Yokogawa, Kenji Omura, Ken-ichi Miyamoto
J. Pharm. Pharmacol., 60(4), 461-465 (2008). Apr

シスプラチン投与後の低ナトリウム血症に対してプロトコル中のナトリウム含有量の標準化が有効だった１症例
山田千代子、河原昌美、長田幸恵、山本憲男、北国憲剛、竹下英理、森　正昭、宮本謙一
日病薬誌, 44(4), 587-591 (2008)

ネオーラルの最適な血中濃度指標を得るための採血時期と投与時期の検証
山本奈歩、松下　良、横川弘一、宮本謙一
TDM研究, 25(2), 69-74 (2008). Apr

Improvement of peripheral microcirculation by iontophoretic application of beraprost sodium.
Norio Takimoto, Keiko Yamamura, Takashi Osada, Tsunehisa Sakurai, Ken-ichi Miyamoto
J. Appl. Ther. Res., 6(3), 9-14 (2008)

2007年度 (#193-208)

Cross talk of tumor necrosis factor-alpha and the renin-angiotensin system in tumor necrosis factor-alpha-induced plasminogen activator inhibitor-1 production from hepatocytes.
Yumie Takeshita, Toshinari Takamura, Hitoshi Ando, Erika Hamaguchi, Akiko Takazakura, Naoto Matsuzawa-Nagata, Shuichi Kaneko
Eur. J. Pharmacol., 579(1-3), 426-432 (2008). Jan

Association of serum NOx level with clustering of metabolic syndrome components in middle-aged and elderly general populations in Japan.
Jun Ueyama, Takaaki Kondo, Ryota Imai, Akiko Kimata, Kanami Yamamoto, Koji Suzuki, Takashi Inoue, Yoshinori Ito, Ken-ichi Miyamoto, Takaaki Hasegawa, Nobuyuki Hamajima
Environ. Health Prev. Med., 13, 36-42 (2008). Jan

専門チームが実践するリスクマネージメント：NSTによる静脈栄養管理
東　敬一郎
日本医療マネージメント学会誌, 9(2), 332-337 (2008)

乳がん化学療法における爪に対する副作用の実態調査
竹下英里、橋本秀子、石本　聖、河原昌美、橋本政和、宮本謙一
医療薬学, 34(1), 79-84 (2008).

げっ歯類におけるシナピン酸の脳保護効果および認知改善効果
唐木田文仁
十全医学会誌, 117(1), 2-9 (2008)

Circadian rhythm of cytochrome P450 2E1 and its effect on disposition kinetics of chlorzoxazone in rats.
Phisit Khemawoot, Kousuke Nishino, Junko Ishizaki, Koichi Yokogawa, Ken-ichi , Miyamoto
Eur. J. Pharmacol., 574(1):71-76 (2007). Nov

Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet.
Naoto Matsuzawa, Toshinari Takamura, Seiichiro Kurita, Hirofumi Misu, Tsuguhito Ota, Hitoshi Ando, Masayoshi Yokoyama, Masao Honda, Yoh Zen, Yasumi Nakanuma, Ken-ichi Miyamoto, Shuichi Kaneko
Hepatology, 46(5):1392-403 (2007). Nov

Caffeine-potentiated chemotherapy for patients with high-grade soft tissue sarcoma: long-term clinical outcome.
Akihiko Takeuchi, Hiroyuki Tsuchiya, Norio Yamamoto, Katsuhiro Hayashi, Kensuke Yamauchi, Masami Kawahara, Ken-ichi Miyamoto, Katsuro Tomita
Anticancer Res., 27(5B), 3489-3495 (2007). Sep-Oct

Influence of chronic hepatic failure on disposition kinetics of valproate excretion through a phase II reaction in rats treated with carbon tetrachloride.
Khemawoot Phisit, Chiharu Maruyama, Hirotaka Tsukada, Hiroyo Noda, Junko Ishizaki, Koichi Yokogawa, Ken-ichi Miyamoto
Biopharm. Drug Dispos., 28 (6), 331-338 (2007). Sep

Evaluation of epidermal growth factor receptor mutation status in serum DNA as a predictor of response to gefitinib (IRESSA).
Hideharu Kimura, Mika Suminoe, Kazuo Kasahara, Takashi Sone, Tomoyuki Araya, Shunichi Tamori, Fumiaki Koizumi Kazuto Nishio, Kenichi Miyamoto, Masaki Fujimura, Shinji Nakao
Br. J. Cancer, 97, 778-784 (2007). Sep

Vinorelbine短時間点滴静注法による静脈炎の予防効果の検討
菅　幸生、原　祐輔、橋本秀子、西上　潤、清水、赤坂、林、米島、中村、井口、笠原寿郎、西村元一、宮本謙一
癌と化学療法, 34(8), 1255-1257 (2007). Aug

Structure-activity relationship of flavonoids for inhibition of epidermal growth factor-induced transformation of JB6 Cl41 cells.
Daisuke Ichimatsu, Masaaki Nomura, Seiji Nakamura, Shuzo Moritani, Koichi Yokogawa, Shinjiro Kobayashi, Tatsuo Nishioka, Ken-ichi Miyamoto
Mol. Carcinog., 46(6):436-445 (2007). Jun

Convenient synthetic method for 3-(3-substituted indol-2-yl)quinoxalin-2-ones as VEGF inhibitor.
Katsuyuki Aoki, Jyun-ichi Koseki, Shuichi Takeda, Masaki Aburada, Ken-ichi Miyamoto
Chem. Pharm. Bull., 55(6), 922-925 (2007). Jun

Inhibitory effects of caffeine analogues on neoplastic transformation: Structure-activity relationship.
Evgeny A. Rogozin, Ki Won Lee, Masaaki Nomura, Ken-ichi Miyamoto, Haoyu Yu, Allan H. Conney, Ann M. Bode, Zigang Dong
Carcinogenesis, 29(6), 1228-1234 (2008). Jun

Toxicity of diazinon and its metabolites increases in diabetic rats.
Jun Ueyama, Dong Wang, Takaaki Kondo, Isao Saito, Kenji Takagi, Kenzo Takagi, Michihiro Kamijima, Tamie Nakajima, Ken-ichi Miyamoto, Shinya Wakusawa, Takaaki Hasegawa
Toxicol Lett., 170(3):229-37 (2007). May

Morphine glucuronosyltransferase activity in human liver microsomes is inhibited by a variety of drugs that are co-administered with morphine.
Yusuke Hara, Miki Nakajima, Ken-ichi Miyamoto, Tsuyoshi Yokoi
Drug Metab. Pharmacokin., 22(2), 103-112 (2007). Apr

2006年度 (#171-192)

Cerebral protective and cognition-improving effects of sinapic acid in rodents.
Fumito Karakida, Yukinobu Ikeya, Mitsuo Tsunakawa, Takuji Yamaguchi, Yasushi Ikarashi, Shuichi Takeda, Masaki Aburada
Biol. Pharm. Bull., 30(3), 514-519 (2007). Mar

Involvement of a1-acid glycoprotein in inter-individual variation of disposition kinetics of ropivacaine following epidual infusion in off-pump coronary artery bypass grafting.
Koichi Yokogawa, Shoko Shimomura, Junko Ishizaki, Tsutomu Shimada, Chie Fukuwa, Masayuki Kawada, Tsunehisa Tsubokawa, Ken Yamamoto, Ken-ichi Miyamoto
J. Pharm. Pharmacol., 59, 67-73 (2007)

Potent platelet-derived growth factor-b receptor (PDGF-b) inhibitors: Synthesis and structure-activity relationships of 7-[3-(cyclohexylmethyl)ureido]-3-[1-methyl- 1H-pyrrolo[2,3-b]pyridin-3-yl]quinoxalin-2(1H)-one derivatives.
Katsuyuki Aoki, Tatsuhiro Obata, Yosuke Yamazaki, Yoshikazu Mori, Hiroko Hirokawa, Jun-ichi Koseki, Tomohisa Hattori, Kazuaki Niitsu, Shuichi Takeda, Masaki Aburada, Ken-ichi Miyamoto
Chem. Pharm. Bull., 55(2), 255-267 (2007)

Synethesis and evaluation of carbamate prodrugs of a phenolic compound.
Yasushi Igarashi, Erika Yanagisawa, Toshihiro Ohshima, Shuichi Takeda, Masaki Aburada, Ken-ichi Miyamoto
Chem. Pharm. Bull., 55(2), 328-333 (2007)

臨床データ利用における個人非特定化に潜む危険性：イニシャルは非特定化のために有効か？
佐藤美佳、古川裕之、松嶋由紀子、横井祐子、宮本謙一
医療薬学, 33(3), 245-250 (2007)

病院薬剤師の立場から見たがん患者への情報提供の変遷：１７年間のアンケート結果から
橋本秀子、宮本謙一
緩和医療, 2(2), 207-210 (2007)

ジゴキシンTDX試薬を用いたデスラノシドの血中濃度測定に関する検討
河原昌美、横川弘一、宮本謙一
TDM研究, 23(4), 268-271 (2006)

Type 2 diabetes mellitus in obese mouse model induced by monosodium glutamate.
Mitsunobu Nagata, Wataru Suzuki, Seiichi Iizuka, Masahiro Tabuchi, Hirofumi Maruyama, Shuichi Takeda, Masaki Aburada, and Ken-ichi Miyamoto
Experimental Animals, 55(2), 109-115 (2006)

Enhancement of drug delivery to bone: Characterization of human tissue-nonspecific alkaline phosphatase tagged with an acidic oligopeptide.
Tatsuo Nishioka, Shunji Tomatsu, Monica A. Gutierrez, Ken-ichi Miyamoto, Georgeta G. Trandafirescu, Patricia L.C. Lopez, Jeffrey H. Grubb, Rie Kanai, Hironori Kobayashi, Seiji Yamaguchi, Gary S. Gottesman, Richard Cahill, Akihiko Noguchi, William S. Sly
Mol. Gen. Metab., 88(3), 244-255 (2006)

The effects of bathing with inorganic salts and carbon dioxide on body temperature, systemic circulation, and food ingestion and absorption.
Satoshi Watanabe, Nobuyuki Imanishi, Taichi Ishizawa, Shigeo Yano, Shuichi Takeda, Ken-ichi Miyamoto, Masaki Aburada, Junichi Iiyama, Kazumi Kawahira
日温気物医誌, 69(3), 167-178 (2006)

Indoor cultivation and cultural characteristics of Wolfiporia cocos Sclerotia using mushroom culture bottles.
Toshiyuki Kubo, Susumu Terabayashi, Shuichi Takeda, Hiroshi Sasaki, Masaki Aburada, Ken-ichi Miyamoto
Biol. Pharm. Bull., 29(6), 1191-1196 (2006)

Pharmacokinetic advantage of intranasal preparation of a novel anti-osteoporosis drug, L-Asp-hexapeptide-conjugated estradiol.
Koichi Yokogawa, Katsuhiro Toshima, Kayo Yamoto, Tatsuo Nishioka, Naoki Sakura, and Ken-ichi Miyamoto
Biol. Pharm. Bull., 29(6), 1229-1233 (2006)

Immunogloblin preparations attenuate organ dysfunction and hemostatic abnormality by suppressing the production of cytokines in lipopolysacch aride-induced disseminated intravascular coagulation in rats.
Hidesaku Asakura, Yoko Takahashi, Anna Kubo, Tomoe Hayashi, Mika Omote, Masahisa Arahata, Yasuko Kadohira, Mio Maekawa, Masahide Yamazaki, Eriko Morishita, Akiyoshi Takami, Tomotaka Yoshida, Ken-ichi Miyamoto, Shinji Nakao
Crit. Care Med., 34(9), 2421-2425 (2006)

Phosphodiesterase 4 inhibitor rolipram potentiates inhibitory effect of calcitonin on osteoclastogenesis
Ken-ichi Miyamoto, Tatsuo Nishioka, Yoshihiro Waki, Masaaki Nomura, Hiromu Katsuta, Koichi Yokogawa, Hitoshi Amano
J. Bone Miner. Metab., 24, 260-265 (2006)

Development of dosage design of hepatic metabolizing drugs using serum albumin level in chronic hepatic failure
Yasunari Mano, Hirotaka Tsukada, Takeshi Kurihara, Masaaki Nomura, Koichi Yokogawa, Ken-ichi Miyamoto
Biol. Pharm. Bull., 29(8), 1692-1699 (2006)

Site-dependent contributions of P-glycoprotein and CYP3A to cyclosporin A absorption, and effect of dexamethasone in small intestine of mice.
Mingji Jin, Tsutomu Shimada, Koichi Yokogawa, Masaaki Nomura, Junko Ishizaki, Yingshi Piao, Yukio Kato, Akira Tsuji, Ken-ichi Miyamoto
Biochem. Pharmacol., 72, 1042-1050 (2006)

VAS法を用いた学生・薬剤師による大学院実務実習・講義の評価
成橋和正、松下　良、清水　栄、山田清文、宮本謙一、木村和子
医療薬学、32(9), 931-939 (2006)

No interplay between the pathways mediating coagulation and inflammation in tissue factor-induced disseminated intravascular coagulation in rats.
Yasuo Ontachi, Hidesaku Asakura, Yoko Takahashi, Masahisa Arahata, Yasuko Kadohira, Mio Maekawa, Mika Omote, Tomotaka Yoshida, Masahide Yamazaki, Eriko Morishita, Ken-ichi Miyamoto, Shinji Nakao
Crit. Care Med., 34(10), 2646-2650 (2006)

Antinociceptive effect of methyleugenol on formalin-induced hyperalgesia in mice.
Shingo Yano, Yasuyuki Suzuki, Mitsutoshi Yuzurihara, Yoshio Kase, Shuichi Takeda, Satoshi Watanabe, Masaki Aburada, Ken-ichi Miyamoto
Eur. J. Pharmacol., 553(1-3), 99-103 (2006)

Obesity-induced increase of CYP2E1 activity in fat tissue and its effect on disposition kinetics of chlorzoxazone in Zucker rats.
Phisit Khemawoot, Koichi Yokogawa, Tsutomu Shimada, Ken-ichi Miyamoto
Biochem. Pharmacol., 73, 155-162 (2006)

Copper- and iron-rich matrices in hepatocellular lipofuscin particles of a young male patient: diagnostic ultrastructures for Wilson disease.
Satoshi Motonishi, Hisao Hayashi, Yoshikazu Fujita, Toshihide Okada, Atsuhiko Kusakabe, Masafumi Ito, Ken-ichi Miyamoto, Toshio Ueno
Ultrastruct. Pathol., 30 (6), 409-414 (2006). Nov-Dec

Preventive effects of Daisaikoto on metabolic disorders in spontaneous obese type II diabetes mice.
Mitsuo Tsunakawa, Tsutomu Shimada, Wataru Suzuki, Mitsunobu Nagata, Shuichi Takeda, Asako Mizuno, Mitsutaka Kosugi, Masaki Aburada
Journal of Traditional Medicines, 23(6), 2006

2005年度 (#144-170)

Effects of 1-benzylxanthines on cyclic AMP phosphodiesterase.
Hirokazu Suzuki, Hiroyuki Sawanishi, Masaaki Nomura, Tsutomu Shimada, Ken-ichi Miyamoto
Biol. Pharm. Bull., 29(1), 131-134 (2006)

Serum aminotransferase activity as a predictor for estimation of total clearance of hepatically metabolized drugs in rats with acute hepatic failure.
Koichi Yokogawa, Akane Ido, Takeshi Kurihara, Yasunari Mano, Masaaki Nomura, Junko Ishizaki, Ken-ichi Miyamoto
Biol. Pharm. Bull., 29(1), 141-145 (2006)

Contribution of intestinal P-glycoprotein and CYP3A to oral bioavailability of cyclosporin A in mice treated with or without dexamethasone.
Mingji Jin, Tsutomu Shimada, Koichi Yokogawa, Masaaki Nomura, Yukio Kato, Akira Tsuji, Ken-ichi Miyamoto
Int. J. Pharm., 309, 81-86 (2006)

Identification of medicinal Atractylodes based on ITS sequences of nrDNA
Mao Shiba, Kenji Kondo, Eiji Miki, Hiroki Yamaji, Takashi Morota, Susume Terabayashi, Shuichi Takeda, Hiroshi Sasaki, Ken-ichi Miyamoto, Masaki Aburada
Biol. Pharm. Bull., 29 (2), 315-320 (2006)

Simultaneous determination of urinary dialkyl phosphate metabolites of organophosphorus pesticides using gas chromatography-mass spectrometry.
Jun Ueyama, Isao Saito, Michihiro Kamijima, Tamie Nakajima, Masahiro Gotoh, Takayoshi Suzuki, Eiji Shibata, Takaaki Kondo, Kenji Takagi, Ken-ichi Miyamoto, Junki Takamatsu, Takaaki Hasegawa, Kenzo Takagi
J. Chromatgr. B, Epub ahead of print, Jan. 2006

入院患者における末梢静脈カテーテルの閉塞に対するヘパリンロックの効果
郡司聖子、古川裕之、宮下知治、西村元一、安藤絹子、坂尾雅子、飛田敦子、山田清文、宮本謙一
医療薬学, 32(2), 87-96 (2006)

Pharmacokinetics of (-)epicatechin 3-O-gallate, glycyrrhetic acid and rhein in healthy male volunteers after the single dose of TJ-8117 (Unpito), a Japanese traditional medicine for renal failure.
Yukiho Takizawa, Yasuharu Mizufara, Toshimi Morita, Yoshio Kase, Shuichi Takeda, Masaki Aburada, Ken-ichi Miyamoto
Jpn. J. Clin. Pharmacol. Ther., 37(1), 21-32, (2006)

Pharmacokinetics of (-)epicatechin 3-O-gallate, glycyrrhetic acid and rhein in healthy male volunteers after multiple dose of TJ-8117 (Unpito), a Japanese traditional medicine for renal failure.
Yukiho Takizawa, Yasuharu Mizufara, Toshimi Morita, Yoshio Kase, Shuichi Takeda, Masaki Aburada, Ken-ichi Miyamoto
Jpn. J. Clin. Pharmacol. Ther., 37(1), 33-40, (2006)

Functional and molecular characterization of adenosine transport at the rat inner blood-retinal barrier
Katsuhiko Nagase, Masatoshi Tomi, Masanori Tachikawa, Ken-ichi Hosoya
Biochimica et Biophysica Acta，1758,13-19 (2006)

ジゴキシンTDX試薬を用いたデスラノシドの血中濃度測定に関する検討
河原昌美、横川弘一、宮本謙一
TDM研究 23(2) ,135-136 (2006)

Antianginal effects of lercanidipine on the vasopressin or methacholine induced anginal model in rats.
Toshinobu Sasaki, Hirofumi Maruyama, Yoshio Kase, Shuichi Takeda, Masaki Aburada
Biol. Pharm. Bull., 28(5), 811-816 (2005)

Selective inducible nitric oxide synthase inhibition attenuates organ dysfunction and elevated endothelin levels in LPS-induced DIC model rats.
Hidesaku Asakura, Risa Asamura, Yasuo Ontachi, Tomoe Hayashi, Masahide Yamazaki, Eriko Morishita, Ken-ichi Miyamoto, Shinji Nakao
J. Thromb. Haemost., 3(5; May), 1050-5 (2005)

局所麻酔薬ropivacaineの?1-酸性糖タンパク結合動態と薬物間相互作用の検討
石﨑純子、下村祥子、福和千恵、嶋田　努、横川弘一、宮本謙一
医療薬学, 31(6), 445-450 (2005)

Inhibition of epidermal growth factor-induced cell transformation and Akt activation by caffeine.
Masaaki Nomura, Daisuke Ichimatsu, Shuzo Moritani, Ichiko Koyama, Zigang Dong, Koichi Yokogawa, and Ken-ichi Miyamoto
Mol. Carcinog., 44(1), 67-76 (2005)

Involvement of ABC transporters on chemosensitivity of human renal cell carcinomas, and regulation of MRP2 expression by conjugated bilirubin.
Masaaki Nomura, Toshio Matsunami, Kayoko Kobayashi, Tadao Uchibayashi, Kiyoshi Koshida, Motohiro Tanaka, Mikio Namiki, Yasuharu Mizuhara, Tetsuo Akiba, Koichi Yakogawa, Shuzo Moritani, and Ken-ichi Miyamoto
Anticancer Res., 25, 2729-2736 (2005)

病棟スタッフからの質問とそれらに対する薬剤師による薬学的対応
真野泰成、西上　潤、打和壽子、井野秀一、岡田俊英、馬渕　宏、宮本謙一
医療薬学,　31(8), 679-685 (2005)

LPS誘発DICモデルに対するPGI2誘導体の効果：凝血学的マーカー、血中サイトカイン濃度に対する影響
久保杏奈、朝倉英策、表　美香、荒幡昌久、門平靖子、前川実生、御舘靖雄、林　朋恵、山崎雅英、森下英理子、吉田知孝、宮本謙一、中尾眞二
血栓止血誌、16(4), 372-377 (2005)

Inhibitory effects of psychotropic drugs on mexiletine metabolism in human liver microsomes: prediction of in vivo drug interactions.
Yusuke Hara, Miki Nakajima, Ken-ichi Miyamoto, Tsuyoshi Yokoi
Xenobiotica, 35(6),549-560 (2005)

Effects of Rikkunnshi-to, a traditional Japanese medicine, on the delay of gastric emptying induced by Ng-nitro-L-arginine.
Toshitaka Kido, Yoichiro Nakai, Yoshio Kase, Iwao Sakakibara, Masaaki Nomura, Shuichi Takeda and Masaki Aburada
J. Pharmacol. Sci., 98, 161-167 (2005)

Synthesis of a capillarisin sulfur-analogue possessing aldose reductase inhibitory activity by selective isopropylation.
Yasushi Igarashi, Hiroaki Kumazawa, Toshihiro Ohshima, Hisanori Satomi, Susumu Terabayashi, Shuichi Takeda, Masaki Aburada, Ken-ichi Miyamoto
Chem. Pharm. Bull., 53(9), 1088-1091 (2005)

The influence of the sennnosides on absorption of glycyrrhetic acid in rats.
Yasuharu Mizuhara, Yukiho Takizawa, Kazuhisa Ishihara, Takayuki Asano, Hirotaka Kushida, Takashi Morota, Yoshio Kase, Shuichi Takeda, Masaaki Aburada, Masaaki Nomura, and Koichi Yokogawa
Biol. Pharm. Bull., 28(19), 1897-1902 (2005)

Reversal of P-glycoprotein-dependent resistance to vinblastine by newly synthesized bisbenzylisoquinoline alkaloids in mouse leukemia P388 cells.
Feng Peng Wang, Li Wang, Jin Song Yang, Masaaki Nomura, Ken-ichi Miyamoto
Biol. Pharm. Bull., 28(10), 1979-1982 (2005)

Pharmacokinetics of TJ-8117(onpi-to), a drug for renal failure (II): Effects of food, repeated administration and renal failure to plasma concentration of [3H]-(-)epicatechin 3-O-gallate in rats.
Yukiho Takizawa, Toshimi Morita, Naoki Fujitsuka, Shouichirou Shindou, Hiroki Tamisawa, Yoshio Kase, Shuichi Takeda, Masaki Aburada, Ken-ichi Miyamoto
Eur. J. Drug Metab. Pharmacokin., 30(3, Jul.-Sep.), 175-180 (2005)

Inhibition of epidermal growth factor-induced cell transformation by tannins
Masaaki Nomura, Hirotaka Tsukada, Zdaisuke Ichimatsu, Hideyuki Ito, Takashi Yoshida, Ken-ichi Miyamoto
Phytochemistry, 66(17), 2038-2046 (2005)

Long-term levothyroxine decreases the oral bioavailability of cyclosporin A by inducing P-glycoprotein in small intestine.
Mingji Jin, Tsutomu Shimada, Miki Shintani, Koichi Yokogawa, Masaaki Nomura, Ken-ichi Miyamoto
Drug Metab. Pharmacokin., 20(5), 324-330 (2005)

Insulin signaling in adipocytes differentiated from mouse stromal MC3T3-G2/PA6 cells.
Satoshi Morito, Kumiko Yaguchi, Mikiko Imada, Chihiro Tachikawa, Shuzo Moritani, Manabu Igarashi, Koichi Yokogawa, Masaaki Nomura, Ken-ichi Miyamoto
Biol. Pharm. Bull., 28(11), 2040-2045 (2005)

実験的胃癌腹膜播種に対する腹腔内化学療法の効果
米村　豊、遠藤良夫、栃折、坂東、川村、嶋田　努、宮本謙一、田中基裕、佐々木琢磨
癌と化学療法, 32(11), 1635-1639 (2005)

2004年度 (#121-143)

行政への第一報が販売・製造中止にいたった健康食品「糖慈源」による低血糖障害症例
真野泰成、金田　学、西上　潤、打和壽子、井野秀一、岡田俊英、馬渕　宏、宮本謙一
日病薬誌、41(1), 37-41 (2005)

Pharmacokinetic advantage of intraperitoneal injection of docetaxel in treatment for peritoneal dissemination of cancer.
Tsutomu Shimada, Massaki Nomura, Koichi Yokogawa, Yoshio Endo, Takuma Sasaki, Ken-ichi Miyamoto, Yutaka Yonemura
J. Pharm. Pharmacol., 57(Jan.), 177-181 (2005)

ビンブラスチン蓄積とプロテインキナーゼC活性に及ぼす12-O-テトラデカノイルホルボール 13-アセテートの効果
丸山博文、谷野伸吾、油田正樹、宮本謙一
薬理と治療, 33(1), 63-69 (2005)

Inhibition of epidermal growth factor-induced cell transformation and Akt activation by caffeine.
Masaaki Nomura, Daisuke Ichimatsu, Shuzo Moritani, Ichiko Koyama, Zigang Dong, Koichi Yokogawa, and Ken-ichi Miyamoto
Mol. Carcinog., submitted 03.12, resubmitted 04.10, acceptable 05.1

Cremophor EL releases cyclosporin A adsorbed on blood cells and blood vessels, and increases apparent plasma concentration of cyclosporin A.
Mingji Jin, Tsutomu Shimada, Koichi Yokogawa, Masaaki Nomura, Hiroyuki Furukawa, Junko Ishizaki, Ken-ichi Miyamoto
Int. J. Pharm., 293, 137-144 (2005)

Role of P-glycoprotein and multidrug resistance-associated protein Mrp2 in renal excretion and brain distribution of pazufloxacin.
Masami Sugie, Mika Miyoshi, Akemi Shimizu, Jun Ueyama, Takuji Yamaguchi, Toshinobu Sasaki, Kenzo Takagi, Mingji Jin, Ken-ichi Miyamoto, Akira Tsuji, and Takaaki Hasegawa
Antimicrob. Agents Chemother., submitted 1/04, accepted 04.7

Antitumor effect of geranylamine derivatives on human hepatoma.
Kiyoshi Akiyama, Takanobu Kumamoto, Shinsuke Wada, Haruka Miura, Masaaki Nomura, Koichi Yokogawa, Ken-ichi Miyamoto
In Vivo, 19, 173-178 (2005)

Discrimination of maidong(麦冬) derived from Ophiopogon and Liriope species by rbcL sequences, and their chemical components and tuber anatomy.
Mao Shiba, Hiroki Yamaji, Kenji Kondo, Hiroyuki Ichiki, Iwao Sakakibara, Susumu Terabayashi, Sakae Amagaya, Masaki Aburada, and Ken-ichi Miyamoto
Natural Medicines, 58(1), 15-21 (2004)

Rapid determination method of caffeine and application to monitoring of caffeine-assisted chemotherapy.Masami Kawahara, Hiromi Kagiyama, Yoshimitsu Kanazawa, Hiroyuki Tsuchiya, Katsuro Tomita, Koichi Yokogawa, and Ken-ichi Miyamoto
Biopharm. Drug Dispos., 25, 61-67 (2004)

Increased effects of MPDAX, a novel xanthine derivative, on antitumor activity of doxorubicin.
Yasuyuki Sadzuka, Tomomi Sugiyama, Hirokazu Suzuki, Hiroyuki Sawanishi, and Ken-ichi Miyamoto
Toxicol Lett., 150, 341-349 (2004)

Phylogenetic relationships among subtaxa in Bupleurum falcatum L. sensu lato (umbelliferae) based on restriction site variation of chloroplast DNA.
Hideki Matsumoto, Shigeki Ohta, Chang-qi Yuan, You-chang Zhu, Minoru Okada and Ken-ichi Miyamoto
J. Japan. Botany, 79, 79-90 (2004)

Disposition kinetics of taxanes after intraperitoneal administration in rats and influence of surfactant vehicles.
Koichi Yokogawa, Mingji Jin, Naho Furui, Masaru Yamazaki, Hiromi Yoshihara, Masaaki Nomura, Hiroyuki Furukawa, Junko Ishizaki, Sachio Fushida, Kouichi Miwa, and Ken-ichi Miyamoto
J. Pharm. Pharmacol., 56, 629-634 (2004)

Significance of Decreased plasma D-dimer levels following lipopolysaccharide-induced disseminated intravascular coagulation in rats.
Hidesaku Asakura, Yoko Sano, Mika Omote, Tomotaka Yoshida, Yasuo Ontachi, Tomoe Mizutani, Minori Kaneda, Masahide Yamazaki, Eriko Morishita, Akiyoshi Takami, Ken-ichi Miyamoto, Shinji Nakao
Int. J. Hematol., 79, 394-399, 2004

Role of fibrinolysis in tissue-factor-induced disseminated intravascular coagulation in rats: an effect of tranexamic acid.
Hidesaku Asakura, Yoko Sano, Masahide Yamazaki, Eriko Morishita, Ken-ichi Miyamoto, Shinji Nakao
Haematologica, 89(6; June), 757-758 (2004)

Effect of intraperitoneal administration of docetaxel on peritoneal dissemination of gastric cancer.
Yutaka Yonemura, Yoshio Endou, Etsurou Bando, Kiyoshi Kuno, Taiichi Kawamura, Hitoshi Kimura, Tsutomu Shimada, Ken-ichi Miyamoto, Takuma Sasaki, and Paul H. Sugarbaker
Cancer Lett., 210(2; July), 189-196 (2004)

Relationship between endothelin and the pathophysiology of tissue factor-induced and lipopolysaccharide-induced disseminated intravascular coagulation in rats: a study examining the effect of an endothelin receptor antagonist
Yukio Suga, Hidesaku Asakura, Tomotaka Yoshida, Mika Omote, Yasuo Ontachi, Tomoe Mizutani, Masahide Yamazaki, Eriko Morishita, Shinji Nakao, Ken-ichi Miyamoto
Blood Coagul. Fibrin., 15(7; Oct.): 593-598 (2004)

業務の効率化・一元化を目的とした新薬剤業務支援システム：その１　麻薬管理システムの構築
原　祐輔、増江俊子、古瀬　裕、阪本由香、午頭義人、宮本謙一
医薬品情報学, 6 (2), 121-124 (2004)

Possible involvement of P-glycoprotein in renal excretion of pazufloxacin in rats.
Akemi Shimizu, Mika Miyoshi, Masami Sugie, Jun Ueyama, Takuji Yamaguchi, Toshinobu Sasaki, Kenzo Takagi, Mingji Jin, Ken-ichi Miyamoto, Akira Tsuji, and Takaaki Hasegawa
Eur. J. Pharmacol., 501(1-3; Oct.), 151-159 (2004)

Beneficial effect of low-molecular-weight heparin against lipopolysaccharide-induced disseminated intravascular coagulation in rats is abolished by coadministration of tranexamic acid.
Hidesaku Asakura, Yoko Sano, Tomotaka Yoshida, Mika Omote, Yasuo Ontachi, Tomoe Mizutani, Masahide Yamazaki, Eriko Morishita, Akiyoshi Takami, Ken-ichi Miyamoto, Shinji Nakao
Intensive Care Med., 30, 1950-1955 (2004)

Inhibitory mechanism of caffeine on insulin-stimulated glucose uptake in adipose cells.
Tetsuo Akiba, Kuniko Yaguchi, Kikue Tsutsumi, Tatsuo Nishioka, Ichiko Koyama, Masaaki Nomura, Koichi Yokogawa, Shuzo Moritani, and Ken-ichi Miyamoto
Biochem. Pharmacol., 68, 1929-1937 (2004)

組織因子誘発ラットDICモデルに対するメシル酸ナファモスタットの効果：凝血学的マーカー・血管作動性物質に対する影響
高橋葉子、朝倉英策、表　美香、荒幡昌久、門平靖子、前川実生、御舘靖雄、林　朋恵、山崎雅英、森下英理子、吉田知孝、宮本謙一、中尾眞二
血栓止血誌、15(6), 535-540 (2004)

2003年度 (#103-120)

Antithrombotic role of nitric oxide in rats under physiological condition.
H. Asakura, M. Okudaira, Y. Ontachi, T. Mizutani, M. Omote, T. Yoshida, M. Kaneda, M. Yamazaki, E. Morishita, A. Takami, K. Miyamoto, S. Nakao
Thromb. Haemost., 91 (1, Jan.), 71-75, 2004

Discrimination of maidong(麦冬) derived from Ophiopogon and Liriope species by rbcL sequences, and their chemical components and tuber anatomy.
Mao Shiba, Hiroki Yamaji, Kenji Kondo, Hiroyuki Ichiki, Iwao Sakakibara, Susumu Terabayashi, Sakae Amagaya, Masaki Aburada, and Ken-ichi Miyamoto
Natural Medicines, 58(1), 15-21 (2004)

Serum aminotransferase activity as a predictor of clearance of drugs metabolized by CYP isoforms in rats with acute hepatic failure induced by carbon tetrachloride.
Koichi Yokogawa, Mao Watanabe, Harunori Takeshita, Masaaki Nomura, Yasunari Mano, and Ken-ichi Miyamoto
Int. J. Pharm., 269(2), 479-489 (2004)

Conjugated bilirubin induces multidrug resistance-associated protein 2 mRNA expression and in vivo cisplatin resistance in rat hepatoma AH66 cells.
Mitsuo Tamai, Yoshie Ito, Koichi Yokogawa, Haruka Miura, Hirotaka Tsukada, Masaaki Nomura, Shuzo Moritani, and Ken-ichi Miyamoto
Anticancer Res., 24, 4781-4788 (2004)

小児West症候群患者におけるACTH投与によるゾニサミド血漿中濃度変動の症例
安田幸代、成橋和正、大谷嘉奈子、清水　栄、鈴木永雄、横川弘一、小泉晶一、宮本謙一
日病薬誌, 40 (3), 263-268 (2004)

Cyclic AMP phosphodiesterase 4 isoenzyme inhibitory activity of (R)- and (S)-isomer of 7-methyl- or 8- alkyl-4,5,7,8-tetrahydroimidazo[2,1-i]-purin-5-one.
Hirokazu Suzuki, Masaaki Nomura, Ken-ichi Miyamoto, Hiroyuki Sawanishi, and Kenji Yamamoto
Biol. Pharm. Bull., 27(3), 357-360 (2004)

Pathophysiology of disseminated intravascular coagulation (DIC) progresses at a different rate in tissue factor-induced and lipopolysaccaride-induced DIC models in rats.
Hidesaku Asakura, Yukio Suga, Tomotaka Yoshida, Yasuo Ontachi, Tomoe Mizutani, Minori Kato, Takako Ito, Eriko Mirishita, Masahide Yamazaki, Ken-ichi Miyamoto, and Shinji Nakao
Blood Coagul. Fibrinolysis, 14 (3; Apr), 221-228 (2003)

骨・軟部肉腫に対するカフェイン併用化学療法と縮小手術
土屋弘行、金澤芳光、高沢宏太郎、山本憲男、河原昌美、宮本謙一、富田勝郎
整形外科, 43, 168-172 (2003)

腹膜播種患者に対するタキサン系抗癌剤の腹腔内投与時における腹水および血漿中濃度推移
古居奈歩，山﨑　賢，横川弘一，伏田幸夫，三輪晃一，宮本謙一
医療薬学，29(3), 263-269 (2003)

アンプル法とプレフィルドシリンジ法による注射剤の混合プロセスにおけるリスクと作業効率の比較分析
古川裕之、小川　充、坂尾雅子、和田出静子、土屋文人、小松原明哲、宮本謙一
医療薬学、29(3), 270-278 (2003)

糖尿病患者が求めるインスリン注入器の検討：タイマー式と万年筆型の比較アンケート解析より
寺田　愛、安藤　仁、野川麻紀、櫻井　勝、野原えりか、山下治久、早川哲雄、宮本謙一、小林　健一、篁　俊成
糖尿病、46(6), 463-467 (2003)

Prostaglandin E2-mediated anabolic effect of a novel inhibitor of phosphodiesterase 4, XT-611, in the in vitro bone marrow culture.
Ken-ichi Miyamoto, Hirokazu Suzuki, Shinya Yamamoto, Yukie Saitoh, Eiji Ochiai, Shuzo Moritani, Koichi Yokogawa, Shohei Kasugai, Hiroyuki Sawanishi, and Hideomi Yamagami
J. Bone Miner. Res., 18(8), 1471-1477 (2003)

Inhibition of osteoclastogenesis by a phosphodiesterase 4 inhibitor XT-611 through synergistic action with endogenous prostaglandin E2.
Hideomi Yamagami, Tatsuo Nishioka, Eiji Ochiai, Kazuyo Fukushima, Masaaki Nomura, Shohei Kasugai, Shuzo Moritani, Koichi Yokogawa, and Ken-ichi Miyamoto
Biochem. Pharmacol., 66(5; Sep.), 801-807 (2003)

Influence of cytarabine and cyclophosphamide to disposition kinetics of cyclosporin A on bone marrow transplantation.
Tsutomu Shimada, Yuki Aoki, Koichi Yokogawa, Masaaki Nomura, Junko Ishizaki, Jun Nishigami, and Ken-ichi Miyamoto
Transplant. Int., 16, 788-793 (2003)

Involvement of the Akt/mTOR pathway on EGF-induced cell transformation.
M. Nomura, Z. He, I. Koyama, K. Miyamoto, and Z. Dong
Mol. Carcinog., 38(1; Sep.), 25-32 (2003)

Voluntary medication error reporting program in a Japanese national University hospital.
Hiroyuki Furukawa, Hisashi Bunko, Fumito Tsuchiya, and Ken-ichi Miyamoto
Ann. Pharmacother., 37(11), 1716-1722 (2003)

大学院修士課程臨床薬学講義ならびに実務実習のVisual Analog Scale法による客観的評価
成橋和正、野村政明、亀井浩行、小野俊介、松下　良、清水　栄、横川弘一、山田清文、鈴木永雄、宮本謙一、木村和子
薬学雑誌、123(11), 973-980 (2003)

High bioavailability of ?-tocopherol loaded into poly(DL-lactic-co-glycolic acid) microspheres in apolipoprotein B knockout mice.
Koichi Yokogawa, Yuichiro Shima, Tomoka Hashimoto, Makoto Hiyajyo, Kaori Kadoyama, Junko Ishizaki, Masaaki Nomura, Ken-ichi Miyamoto
Pharm. Res., 20 (11), 1846-1850 (2003)

2002年度 (#66-102)

Disposition kinetics of α-tocopherol in apolipoprotein B knockout mice.
Koichi Yokogawa, Yuichiro Shima, Tomoka Hashimoto, Makoto Hiyajyo, Kaori Kadoyama, Junko Ishizaki, Masaaki Nomura, and Ken-ichi Miyamoto
Pharm. Res., 20 (3), 368-372 (2003)

Management of information about adverse events in clinical trials.
Hiroyuki Furukawa，Yukiko Matsushima，Yukie Osada, Eiko Yokoyama, Yuhko Yokoi, Junko Ishizaki, and Ken’ichi Miyamoto
Jpn. J. Pharm. Health Care Sci., 29 (2), 140-146 (2003)

カラムスイッチングHPLCシステムによるゾニサミドの高感度測定法の評価
金　明姫，西尾　忠，竹田和喜，横川弘一，宮本謙一
医療薬学，29 (2), 178-183 (2003)

医療用機器のリスク低減のための評価方法について（薬剤混注作業におけるアンプル法とプレフィルドシリンジ法との比較検討を事例として）
小川　充，小松原明哲，古川裕之，宮本謙一，坂尾雅子，和田出静子
人間生活工学，4 (1), 34-40 (2003)

個別薬物療法のための血漿中蛋白非結合形disopyramide濃度測定の有用性
大川浩子，渡辺真生，斎藤義正，打和壽子，藤井　奨，井野秀一，横川弘一，宮本謙一
臨床薬理，34 (1), 1-6 (2003)

臨床試験における有害事象情報の効率的な提供システムの構築
古川裕之，内潟将宏，松嶋由紀子，長田幸恵，横山英子，石崎純子，清水　栄，神谷　晃，宮本謙一
臨床薬理，34 (1), 7-12 (2003)

臨床試験（治験）と臨床研究における安全管理－薬剤師の役割は？－
古川裕之
PHARMACOANESTHESIOLOGY, 15(1), 50-55(2003)

Causative agent of vascular pain among photodegradation products of dacarbazine.
Mariko Asahi, Ryo Matsushita, Masami Kawahara, Tomoyuki Ishida, Chie Emoto, Nagao Suzuki, Osamu Kataoka, Chisato Mukai, Miyoji Hanaoka, Junko Ishizaki, Koichi Yokogawa, and Ken-ichi Miyamoto
J. Pharm. Pharmacol., 54, 1117-1122 (2002)

Modulation of noradrenaergic and serotonergic transmission by noxious stimili and intrathecal morphine differs in the dorsal raphe nucleus of anesthetized rat: in vivo voltammetric studies.
Toichiro Chuma, Kyoji Taguchi, Masatoshi Kato, Kenji Abe, Iku Utsunomiya, Ken-ichi Miyamoto, and Tadashi Miyatake
Neurosci. Res., 44, 37-44 (2002)

Induction of vasoactive substances differes in LPS-induced and TF-induced DIC models in rats.
H. Asakura, M. Okudaira, T. Yoshida, Y. Ontachi, M. Yamazaki, E. Morishita, K. Miyamoto, and S. Nakao
Thromb. Haemost., 88 (4), 663-667 (2002)

Effects of xanthine derivatives on the influx and efflux of doxorubicin in P388 and DOX-resistant P388 leukemia cells.
Y. Sadzuka, Y. Egawa, H. Sawanishi, K. Miyamoto, and T. Sonobe
Toxicol. Lett., 135, 137 (2002)

Lowered blood concentration of tacrolimus and its recovery with changes in expression of CYP3A and P-glycoprotein after high-dose steroid therapy
Tsutomu Shimada, Ai Terada, Koichi Yokogawa, Hiroko Kaneko, Masaaki Nomura, Kyosuke Kaji, Shuichi Kaneko, Ken-ichi Kobayashi and Ken-ichi Miyamoto
Transplantation, 74 (10), 1419-1424 (2002)

フレームレス式原子吸光光度計によるリチウム高感度測定法の確立
長瀬克彦，畑　武生，河原昌美，松下　良，横川弘一，宮本謙一
TDM研究，19(2), 217-218 (2002)

JA岐阜厚生連中農病院における院内感染対策に対する薬剤師活動指針策定のための抗生物質使用状況調査
寺町ひとみ，畠山裕充，立木　智，大塚守紀，成橋和正，松下　良，今井幸夫，宮本謙一，辻　彰
医療薬学，28(4), 339-346 (2002)

成人MRSA患者におけるバンコマイシンの初期投与量推定法の比較検討
寺町ひとみ，畠山裕充，松下　良，今井幸夫，宮本謙一，辻　彰
医療薬学，28(6), 530-540 (2002)

口渇誘発薬が小児患者における化学療法による口内炎発生の危険性を増大させる可能性がある
成橋和正，稲木正樹，大谷嘉奈子，古川裕之，清水　栄，鈴木永雄，横川弘一，小泉晶一，宮本謙一
医療薬学，28(6), 551-558 (2002)

胃癌腹膜播種症例に対するDocetaxel（Taxotere）腹腔内投与時の薬物動態と安全性の検討
伏田幸夫，古居奈歩，木南伸一，二宮　致，藤村　隆，西村元一，太田哲生，横川弘一，宮本謙一，三輪晃一
癌と化学療法, 29(10), 1759-1763 (2002)

胃癌腹膜播種症例に対するPaclitaxel(Taxol)腹腔内投与時の薬物動態と安全性の検討
伏田幸夫，古居奈歩，木南伸一，二宮　致，藤村　隆，西村元一，太田哲生，横川弘一，宮本謙一，三輪晃一
癌と化学療法, 29(12), 2164-2167 (2002)

組織因子およびLPS誘発ラットDICモデルの経時的病態比較
菅　幸生，朝倉英策，吉田知孝，森下英理子，山崎雅英，青島敬二，御舘靖雄，水谷朋江，加藤みのり，伊藤貴子，宮本謙一，中尾眞二
血栓止血誌, 13(1), 41-46 (2002)

LPS誘発ラットDICモデルにおけるエンドセリンの役割
菅　幸生，朝倉英策，吉田知孝，森下英理子，山崎雅英，青島敬二，御舘靖雄，水谷朋江，加藤みのり，伊藤貴子，宮本謙一，中尾眞二
血栓止血誌, 13(2), 169-174 (2002)

組織因子誘発ラットDICモデルにおける出血症状・臓器症状の発現機序：抗線溶剤投与に伴う影響
佐野陽子，朝倉英策，吉田知孝，浅村梨沙，山崎雅英，森下英理子，御舘靖雄，水谷朋恵，金田みのり，伊藤貴子，宮本謙一，中尾眞二
血栓止血誌, 13(4), 319-325 (2002)

ラットDICモデルにおける血管作動性物質の変動：抗凝血薬投与に伴う影響
佐野陽子，朝倉英策，吉田知孝，浅村梨沙，山崎雅英，森下英理子，御舘靖雄，水谷朋恵，金田みのり，伊藤貴子，宮本謙一，中尾眞二
血栓止血誌, 13(6), 485-492 (2002)

学術委員会第3小委員会　薬剤管理指導業務支援システムの調査・研究
岩瀬利康，飯塚信光，小林茂久，高木章次，堂川嘉久，西上　潤，星　亮次
日病薬誌，38(1)，97-98 (2002)

薬剤管理指導における能動的医薬品情報提供のための下剤の使用状況調査
小田中みのり，旭　満里子，横川弘一，宮本謙一
薬学雑誌，122 (1), 89-95 (2002)

診療報酬改訂の服薬指導と収入への影響－金沢大学医学部附属病院小児科の薬剤管理指導業務について－．
金谷圭子，永平廣則，古川裕之，松下　良，分校久志，宮本謙一，木村和子
薬学雑誌，122(7), 481-485 (2002)

治験依頼者における有害事象の管理体制についての調査研究
古川裕之，内潟将宏，松嶋由紀子，長田幸恵，横山英子，松田静枝，石崎純子，清水　栄，分校久志，宮本謙一
臨床薬理，33(6), 281-286 (2002)

市販直後調査の効果的な実施方法についての分析
古川裕之，金谷圭子，山崎威志，高木敏治，増江俊子，石崎純子，木村和子，宮本謙一
臨床薬理，33 (6), 287-294 (2002)

黄連解毒湯およびその構成生薬の心・血管系に対する作用：ほてり・顔面紅潮に対する有効性の検討
脇田広美，宮本謙一
和漢医薬誌，19 (6), 230-237 (2002)

オウゴンの心・血管系に対する作用：baicalinの血管平滑筋収縮作用およびその作用機序
脇田広美，鈴木永雄，宮本謙一
和漢医薬誌，19 (6), 238-245 (2002)

Involvement of multidrug resistance-associated protein 2 in in vivo cisplatin resistance of rat hepatoma AH66 cells.
Yoshie Itoh, Mitsuo Tamai, Koichi Yokogawa, Masaaki Nomura, Shuzo Moritani, Hiroshi Suzuki, Yuichi Sugiyama, and Ken-ichi Miyamoto
Anticancer Res., 22, 1649-1654 (2002)

Costunolide induces differentiation of human leukemia HL-60 cells.
J.H. Choi, B.R. Seo, S.H. Seo, K.T. Lee, J.H. Park, J.W. Choi, Y. Itoh, and K. Miyamoto
Arch. Pharm. Res., 25(4), 480-484 (2002)

Modulation of mdr1a and CYP3A gene expression in the intestine and liver as possible cause of changes in the cyclosporin A disposition kinetics by dexamethasone.
Koichi Yokogawa, Tsutomu Shimada, Yasuhiko Higashi, Yoshie Itoh, Toshiko Masue, Junko Ishizaki, Mariko Asahi, and Ken-ichi Miyamoto
Biochem. Pharmacol., 63, 777-783 (2002)

Selective phosphodiesterase type 4 inhibitors reduce the prolonged survival of eosinophils stimulated by granulocyte-macrophage colony-stimulating factor.
Masayuki Takeuchi, Yasuaki Tatsumi, Kiyoyuki Kitaichi, Kenji Baba, Ryujiro Suzuki, Eiji Shibata, Kenji Takagi, Ken-ichi Miyamoto, Takaaki Hasegawa, and Kenzo Takagi
Biol. Pharm. Bull., 25(2), 184-187 (2002)

Evaluation of predictability for vancomycin dosage regimens by the Bayesian method with Japanese population pharmacokinetic parameters.
Hitomi Teramachi, Hiromi Hatayama, Ryo Matsushita, Yukio Imai, Ken-ichi Miyamoto, and Akira Tsuji
Biol. Pharm. Bull., 25(10), 1333-1338 (2002)

Beneficial effect of JTV-803, a new synthetic inhibitor of activated factor X, against both lipopolysaccharide-induced and tissue factor-induced disseminated intravascular coagulation in rat models.
Hidesaku Asakura, Tsukasa Ichino, Yukio Suga, Tomoe Mizutani, Minori Kato, Takako Itoh, Masahide Yamazaki, Keiji Aoshima, Eriko Morishita, Masanori Saito, Ken-ichi Miyamoto, and Shinji Nakao
Blood Coagul. Fibrinolysis, 13(3: April), 233-239 (2002).

Synthesis and cyclic AMP phosphodiesterase 4 isoenzyme inhibitory activity of heterocycle condensed purines.
Hirokazu Suzuki, Manabu Yamamoto, Susumu Shimura, Ken-ichi Miyamoto, Kenji Yamamoto, and Hiroyuki Sawanishi,
Chem. Pharm. Bull., 50(9), 1163-1168 (2002).

Marked difference in pathophysiology between tissue factor- and lipopolysaccharide-induced disseminated intravascular coagulation models in rats.
Hidesaku Asakura, Yukio Suga, Keiji Aoshima, Yasuo Ontachi, Tomoe Mizutani, Minori Kato, Masanori Saito, Eriko Morishita, Masahide Yamazaki, Akiyoshi Takami, Ken-ichi Miyamoto, and Shinji Nakao
Crit. Care Med., 30(1), 161-164 (2002).

2001年度 (#32-65)

Decreased plasma activity of antithrombin or protein C is not due to consumption coagulopathy in septic patients with disseminated intravascular coagulation.
Hidesaku Asakura, Yasuo Ontachi, Tomoe Mizutani, Minori Kato, Takako Ito, Masanori Saito, Eriko Morishita, Masahide Yamazaki, Keiji Aoshima, Akiyoshi Takami, Tomotaka Yoshida, Yukio Suga, Ken-ichi Miyamoto, and Shinji Nakao
Eur. J. Haematol., 67, 170-175 (2001)

Phosphodiesterase 4 isoenzyme inhibitory activity of 3-phenylxanthine and 4-phenyl[i]condensed-　purines.
Hirokazu Suzuki, Hiroyuki Sawanishi, Kenji Yamamoto, Koichi Yokogawa and Ken-ichi Miyamoto
Chem. Pharm. Bull., 49 (2), 188-191 (2001)

Beneficial effect of the active form of vitamin D3 against LPS-induced DIC but not against tissue-factor-induced DIC in rat models.
Hidesaku Asakura, Kenji Aoshima, Yukio Suga, Masahide Yamazaki, Eriko Morishita, Masanori Saito, ken-ichi Miyamoto, and Shinji Nakao
Thromb. Haemost., 85, 287-290 (2001)

Transactivation of AP-1 in AP-1-luciferase reporter transgenic mice by arsenite and arsenate.
C. Huang, A.M. Bode, N.Y. Chen, W.Y. Ma, J. Li, M. Nomura, and Z. Dong
Anticancer Res., 21(1A), 261-267 (2001)

Selective delivery of estradiol to bone by aspartic acid oligopeptide and its effects on ovariectomized mice.
Koichi Yokogawa, Kazuhiro Miya, Tohru Sekido, Yasuhiko Higashi, Masaaki Nomura, Ryuichi Fujisawa, Keiko Morito, Yukito Masamune, Yoshihiro Waki, Shohei Kasugai, and Ken-ichi Miyamoto
Endocrinology, 142(3), 1228-1233 (2001)

Elevated levels of free tissue factor pathway inhibitor antigen in cases of disseminated intravascular coagulation caused by various underlying diseases.
H. Asakura, Y. Ontachi, T. Mizutani, M. Kato, M. Saito, E. Mirishita, M. Yamazaki, Y. Suga, A. Takami, K. Miyamoto and S. Nakao
Blood Coagul. Fibrinolysis, 12, 1-8 (2001)

Kalopanaxsaponin A is a basic saponin structure for the anti-tumor activity of hederagenin monodesmosides.
Hee-Joun Park, Sang-Hyuk Kwon, Joo-Han Lee, Kyou-Heung Lee, Ken-ichi Miyamoto, and Kyung-Tae Lee
Planta Med., 67(Mar.), 118-121 (2001)

Effect of g-butyrobetaine on fatty liver in juvenile visceral steatosis mice.
Yasuhiko Higashi, Koichi Yokogawa, Noriko Takeuchi, Ikumi Tamai, Masaaki Nomura, Noriyoshi Hashimoto, Jun-ichiro Hayakawa, Ken-ichi Miyamoto, and Akira Tsuji
J. Pharm. Pharmacol., 53 (4), 527-533 (2001)

Depressed plasma activity of plasminogen or alfa2 plasmin inhibitor is not due to consumption cagulopathy in septic patients with disseminated intravascular coagulation.
H. Asakura, Y. Ontachi, T. mizutani, M. Kato, T. Ito, M. Saito, E. Morishita, M. Yamazaki, Y. Suga, K. Miyamoto, and S. Nakao
Blood Coagul. Fibrinolysis, 12 (4), 275- 281(2001)

All-trans retinoic acid is partially effective against lipopolysaccharide-induced but not against tissue-factor-induced disseminated intravascular coagulation in rat models.
H. Asakura, K. Aoshima, T. Ichino, Y. Suga, M. Saito, E. Morishita, M. Yamazaki, Y. Ontachi, T. Mizutani, M. Kato, K. Miyamoto, and S. Nakao
Blood Coagul. Fibrinolysis, 12 (4), 301-306 (2001)

Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice.
N. Chen, M. Nomura, Q.B. She, W.Y. Ma, A.M. Bode, L. Wang, R.A. Flavell, and Z. Dong
Cancer Res., 61(10: May), 3908-3912 (2001)

Organ-specific activation of activator protein-1 in transgenic mice by 12-O-tetradecanoyl- phorbol-13-acetate with different administration methods.
S. Zhong, J.A. Quealy, A.M. Bode, M. Nomura, A. Kaji, W.Y. Ma, and Z. Dong
Cancer Res., 61(10: May), 4084-91 (2001)

Suppression of cell transformation and induction of apoptosis by caffeic acid phenetyl ester.
Masaaki Nomura, Akira Kaji, Wei-Ya Ma, Ken-ichi Miyamoto, and Zigang Dong
Mol. Carcinog., 31(2: June), 83-89 (2001)

Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.
Y. Zhang , Z. Dong, M. Nomura, S. Zhong, N. Chen, A.M. Bode, and Z. Dong
J. Biol. Chem., 276(24: June), 20913-20923 (2001)

Mitogen- and stress-activated protein kinase-1 mediated activation of Akt by ultraviolet B irradiation.
Masaaki Nomura, Akira Kaji, Wei-Ya Ma, Shuping Zhong, Guangming Liu, Tim Bowden, Ken-ichi Miyamoto, and Zigang Dong
J. Biol. Chem., 276(27: July), 25558-25567 (2001)

Novel drug delivery system to bone by acidic oligopeptide: Pharmacokinetic characteristics and pharmacological potential.
Tohru Sekido, Naoki Sakura, Yasuhiko Higashi, Kazuhiro Miya, Youko Nitta, Masaaki Nomura, Hiroyuki Sawanishi, Keiko Morito, Yukito Masamune, Shohei Kasugai, Koichi Yokogawa and Ken-ichi Miyamoto
J. Drug Targeting, 9, 111-122 (2001)

Indivisual patient-by-patient surveillance of the antimicrobial usage among inpatients in Kanazawa University Hospital.
Kazumasa Naruhashi, Mariko Asahi, Yasuko Higuchi, Ryo Matsushita, Sakae Shimizu, Kazuko Kimura, Nagao Suzuki, Koichi Yokogawa, Shin-ichi Fujita, and Ken-ichi Miyamoto
Jpn. J. Hosp. Pharm. Heath Care Sci., 27(3), 205-211 (2001)

Decreased plasma activity of antithrombin or protein C is not due to consumption coagulopathy in septic patients with disseminated intravascular coagulation.
H. Asakura, Y. Ontachi, T. Mizutani, M. Kato, T. Ito, M. Saito, E. Morishita, M. Yamazaki, K. Aoshima, A. Takami, T Yoshida, Y. Suga, K. Miyamoto, and S. Nakao
Eur. J. Haematol., 67(3: Sep.), 170-175 (2001)

Enhancement of in vivo antitumor activity of a novel antimitotic 1-phenylpropenone derivative, AM-132, by tumor necrosis factor-? or interleukin-6.
Yasuaki Tatsumi, Hitoshi Arioka, Shun-ichi Ikeda, Hisao Fukumoto, Ken-ichi Miyamoto, Kazuya Fukuoka, Yuichiro Ohe, Nagahiro Saijo, and Kazuto Nishio
Jpn. J. Cancer Res., 92, 768-777 (2001)

Apoptosis-inducing costunolide and a novel acyclic monoterpen from the stem bark of Magnolia sieboldii.
Hee Juhn Park, Sang Hyuk Kwon, Yong Nam Han, Jong Won Choi, Ken-ichi Miyamoto, Sung Ho Lee, and Kyung Tae Lee
Arch. Pharm. Res., 24(4), 342-348 (2001)

Tectorigenin, an isoflavone of Pueraria thunbergiana, induces differentiation and apoptosis on human promyelocytic leukemia HL-60 cells.
Kyung-Tae Lee, Il-Cheol Sohn, Young-Kwan Kim, Jung-Hye Choi, Jong-Won Choi, Hee-Juhn Park, Yoshie Itoh, and Kenichi Miyamoto
Biol. Pharm. Bull., 24(10), 1117-1121 (2001)

Kinetic phenotypic diagnosis of N-acetylation polymorphism in patients based on ratio of urinary metabolites of salicylazosulfapyridine.
Koichi Yokogawa, Tohru Nakaharu, Junko Ishizaki, Eijiro Ozaki, Yasuo Takeda, Hiroshi Mabuchi, Ryo Matsushita, Kazuko Kimura, Emi Nakashima, Fujio Ichimura and Ken-ichi Miyamoto
Int. J. Pharm., 229(1-2: Oct), 183-191 (2001)

Enhancement of endotherial nitric oxide production by chenodeoxycholic acids in patients with hepatobiliary diseases.
K. Chisaki, T. Nakajima, K. Iwasawa, H. Iida, A. Matsunoto, M. Tada, Y. Komatsu, K. Hirose, K. Miyamoto, Y. Okuda, Y. Shiratori, A. Goto, Y. Hirata, R. Nagai, and M. Omata
Jpn. Heart J., 42(3: May), 339-353 (2001)

Inhibitory mechanisms of tea polyphenols on the ultraviolet B-activated phosphatidylinositol-3- kinase-dependent pathway.
Masaaki Nomura, Akira Kaji, Zhiwei He, Wei-Ya Ma, Ken-ichi Miyamoto, Chung S. Yang, and Zigang Dong
J. Biol Chem., 276(49: Dec.), 46624-46631 (2001)

Effect of meropenem on disposition kinetics of valproate and its metabolites in rabbits.
Koichi Yokogawa, Satsuki Iwashita, Akira Kubota, Youko Sasaki, Junko Ishizaki, Masami Kawahara, Ryo Matsushita, Kazuko Kimura, Fujio Ichimura and Ken-ichi Miyamoto
Pharm. Res., 18(9), 1320-1326 (2001)

Dacarbazine の光分解によって生成する発痛物質の探索.
河原昌美，石田智之，江本千恵，松下　良，市村藤雄，片岡　治，向　智里，花岡美代次，石崎純子，旭　満里子，宮本謙一
臨床薬理，32 (1), 15-22 (2001)

新GCP下の臨床試験における服薬コンプライアンスに関する調査.
古川裕之，陶山和明，河原昌美, 石崎純子, 松嶋由紀子，長田幸恵，松田静枝，清水 栄, 宮本謙一
臨床薬理，32 (1), 35-42 (2001)

ステロイド剤の服用・使用状況および効果・副作用発現に対する患者の意識調査：アンケートをもとに今後の薬剤管理指導への活用.
大川浩子，旭　満里子，鏑木真理子，成橋和正，駒井清暢，宮本謙一
日本病院薬剤師会雑誌，37(6), 783-786 (2001)

LPSまたは組織因子誘発ラットDICモデルにおける血管作動性物質の動態の比較
奥平真理子，朝倉英策，佐野陽子，菅　幸生，山崎雅英，青島敬二，森下英理子，斉藤正典，御館靖雄水谷朋恵，加藤みのり，伊藤貴子，宮本謙一，中尾眞二
血栓止血誌，12(4), 273-279 (2001)

生理的状態のラットにおける一酸化窒素の抗血栓性の役割
奥平真理子，朝倉英策，佐野陽子，菅　幸生，山崎雅英，青島敬二，森下英理子，斉藤正典，御館靖雄，水谷朋恵，加藤みのり，伊藤貴子，宮本謙一，中尾眞二
血栓止血誌，12(4), 288-293 (2001)

パーキンソン病患者のカルテ調査による薬剤の使用状況とADLに及ぼす影響.
大川浩子，谷本明日香，旭　満里子，成橋和正，松下　良，坂尻顕一，宮本謙一
医療薬学, 27(4), 392-398 (2001)

超選択的動注化学療法による下咽頭喉頭癌治療：シスプラチン単剤に対するシスプラチン＋ピラルビシン併用療法の有効性の検討.
吉崎智一，志賀英明，真田順一郎，寺山　昇，松井　修，石崎純子，宮本謙一，河合晃充，古川　仭
日気食会報，52(5), 400-408 (2001)

臨床試験における有害事象報告の問題点の分析
古川裕之，内潟将宏，石崎純子，松嶋由紀子，長田幸恵，松田静枝，横山英子，清水　栄，分校久志，宮本謙一
臨床薬理，32(6), 287-294 (2001)

医薬品に関連したリスクマネジメント戦略における処方オーダリングシステムの可能性についての分析
古川裕之，土屋文人，大西 久，増江俊子，分校久志，宮本謙一
医療情報学，21(1), 69-76 (2001)

2000年度　(#20-31)

Selective drug delivery system to bone: Small peptide (Asp)6 conjugation.
Shohei Kasugai, Ryuichi Fujisawa, Yoshihiro Waki, Ken-ichi Miyamoto, Keiichi Ohya
J. Bone Miner. Res., 15, 936-943 (2000)

Uptake of imipramine in rat liver lysosomes in vitro and its inhibition by basic drugs
J. Ishizaki, K. Yokogawa, F. Ichimura, and S. Ohkuma
J. Pharmacol. Exp.Ther. 294(3): 1088-1098 (2000)


Reversal of anticancer drug resistance by macrolide antibiotics in vitro and in vivo.
Li Wang, Cai Shao Hui, Kiyoyuki Kitaichi, Kenji Takagi, Kenzo Takagi, Miyuki Sakai, Yasuaki Tatsumi, Koichi Yokogawa, Ken-ichi Miyamoto, Takaaki Hasegawa.
Clin. Expl. Pharmacol. Physiol., 27, 587-593(2000)

Differentiation-inducing effect of magnolilalide, a 1b-hydroxyeudesmanolide isolated from Cichorium intybus on human leukemia cells.
Kyung-Tae Lee, Joo-Il Kim, Hee-Juhn Park, Ki-Oug Yoo, Yong-Nam Hanand Ken-ichi Miyamoto
Biol. Pharm. Bull., 23, 1005-1007 (2000)

Inhibition of ultraviolet B-induced AP-1 activation by theaflavins from black tea.
Masaaki Nomura, Wei-Ya Ma, Chuanshu Huang, Chung S. Yang, G. Tim Browden, Ken-ichi Miyamoto and Zigang Dong
Mol. Carcinog., 28 (Aug.), 148-155 (2000)

GABAergic contribution to rat bladder hyperactivity after middle cerebral artery occlusion.
Sayoko Kanie, Osamu Yokoyama, Kazuto Komatsu, Koichi Kodama, Satoshi Yotsuyanagi, Susumu Niikura, Yasuhiro Nagasaka, Ken-ichi Miyamoto, and Mikio Namiki
Am. J. Physiol., 279 (Sep.), R1230-R1238 (2000)

臨床試験におけるモニタリング実施上の問題点..
石崎純子，神田哲雄，古川裕之，松田静枝，中川清治，宮本謙一
臨床薬理，31, 97-98 (2000)

先天的カルニチン欠損JVSマウスの脂肪肝に与えるγ－ブチロベタインの効果.
横川弘一，東　康彦，玉井郁巳，辻　彰，橋本憲佳，早川純一郎，宮本謙一
臨床薬理，31, 443-444 (2000)

組織因子およびLPS誘発ラットDICモデルに対するall-trans retinoic acid、活性化ビタミンD3、低分子ヘパリンの薬効比較検討.
市野　典、朝倉英策、青島敬二、山崎雅英、菅　幸生、奥平真理子、森下英理子、斎藤正典、御舘靖雄、水谷朋恵、加藤みのり、宮本謙一、松田　保
血栓止血誌，11, 65-73 (2000)

MERIT－９紹介状形式によるHIS－PC間病診連携
木村通男，大江和彦，作佐部太也，佐々木文夫，安藤裕，川真田文章，土屋文人，古川裕之，清谷哲郎，廣瀬康行，山本隆一，坂本憲広，秋山昌範，山下芳範，谷 重喜，山口雅敏，永井 肇，阿曽沼元博，藤江 昭，稲岡則子
医療情報学，20(2):87 ?94，2000

処方オーダシステムに登録されている用法の他施設比較調査
清水秀行，土屋文人，古川裕之，下堂薗権洋，永井肇
帝京医学雑誌，23(3):283?289，2000

ＷＷＷを利用した注射剤混合に伴う変化情報入力・検索システムの構築
古川裕之，分校久志，西村久雄，宮本謙一，佐藤保，岩本喜久生，折井孝男，伊賀立二，木内貴弘，櫻井恒太郎
医療情報学，20(3):199?207，2000

1999年度　（＃1-19）

Walker256/S carcinosarcoma causes osteoporosis-like changes through ectopical secretion of luteinizing hormone-releasing hormone.
Yoshihiro Waki, Masaaki Nomura, Shohei Kasugai, Keiichi Ohya and Ken-ichi Miyamoto
Cancer Res., 59, 1219-1224 (1999)

Decreased tissue distribution of L-carnitine in juvenile visceral steatosis mice.
Koichi Yokogawa, Yasuhiko Higashi, Ikumi Tamai, Masaaki Nomura, Noriyashi Hashimoto, Hiroko Nikaido, Jun-ichiro Hayakawa, Ken-ichi Miyamoto and Akira Tsuji
J. Pharmacol. Expl. Ther., 289 (1) , 224-230 (1999)

Effects of XT-44 , a phosphodiesterase 4 inhibitor, in osteoblastogenesis and osteoclastogenesis in culture and its therapeutic effects in rat osteopenia models.
Yoshihiro Waki, Takashi Horita, Ken-ichi Miyamoto, Keiichi Ohya and Shohei Kasugai
Jpn. J. Pharmacol., 79, 477-483 (1999)

Postmenopause-like bone loss by mammary carcinoma Walker256/S which secretes luteinizing hormone-releasing hormone.
Yoshihiro Waki, Ken-ichi Miyamoto, Shinya Yamamoto, Yukie Saitoh, Shohei Kasugai and Keiichi Ohya
Jpn. J. Pharmacol., 80, 119-125 (1999)

Studies on constituents with cytotoxic activity from the stem bark of Syringa velutina.
Hee-Juhn Park, Myung-Sun Lee, Kyung-Tae Lee, Il-Cheol Sohn, Yong-Nam Han, and Ken-ichi Miyamoto Chem. Pharm. Bull., 47, 1029-1031 (1999)

Adhesive interaction of highly malignant hepatoma AH66F cells with mesothelial cells.
Masaaki Nomura, Yuhki Sugiura, Yasuaki Tatsumi, and Ken-ichi Miyamoto Biol. Pharm. Bull., 22, 738-740 (1999)

Enhanced efficacy of 1-methyl-3-propyl-7-butylxanthine on the antitumor activity of doxorubicin against doxorubicin-resistant P388 leukemia.
Yasuyuki Sadzuka, Tomomi Sugiyama, Hiroyuki Sawanishi and Ken-ichi Miyamoto Cancer Lett., 138, 5-11 (1999)

P-glycoprotein-dependent tissue distribution of tacrolimus:Studies in mdr1a knockout mice
Koichi Yokogawa, Hiroko Konishi, Ikumi Tamai, Megumu Takahashi, Masaaki Nomura, Shuzo Moritani, Ken-ichi Miyamoto and Akira Tsuji Pharm. Res., 16, 1213-1218 (1999)

Characteristics of L-carnitine transport in cultured human hepatoma HLF cells.
Koichi Yokogawa, Kazuhiro Miya, Ikumi Tamai, Yasuhiko Higashi, Masaaki Nomura, Ken-ichi Miyamoto, and Akira Tsuji J. Pharm. Pharmacol., 51, 935-940 (1999)

Condensed-purines syntheses of tetrahydro-1,4-diazepino[1,2,3-gh]purin-2-one and hexahydro-1,4-diazocino- [1,2,3-gh]purin-2-one.
Horikazu Suzuki, Hiroyuki Sawanishi, Kenji Yamamoto, and Ken-ichi Miyamoto Chem. Pharm. Bull., 47, 1322-1325 (1999)

Loss of wild-type carrier-mediated L-carnitine transport activity in hepatocytes of juvenile visceral steatosis mice.
Koichi Yokogawa, Masayuki Yonekawa, Ikumi Tamai, Rikiya Ohashi, Yasuaki Tatsumi, Yasuhiko Higashi, Masaaki Nomura, Noriyoshi Hashimoto, Hiroko Nikaido, Jun-ichiro Hayakawa, Jun-ichi Nezu, Asuka Oku, Miyuki Shimane, Ken-ichi Miyamoto, and Akira Tsuji Hepatology, 30, 997-1001 (1999)

In vivo cisplatin resistance depending upon canalicular multispecific organic anion transporter (cMOAT).
Tomoyoshi Minamino, Mitsuo Tamai, Yoshie Itoh, Yasuaki Tatsumi, Masaaki Nomura, Koichi Yokogawa, Hiroshi Suzuki, Yuichi Sugiyama, Tohru Ohshima, and Ken-ichi Miyamoto Jpn. J. Cancer Res., 90, 1171-1178 (1999)

Hypericin induces both differentiation and apoptosis in human promyelocytic leukemia HL-60 cells.
Kyung-Tae Lee, Joo-Il Kim, Young-Soo Rho, Seoung-Goo Chang, Jee-Chang Jung, Jae-Hoon Park, Hee-Joun Park and Ken-ichi Miyamoto Biol. Pharm. Bull., 22, 1271-1274 (1999)

Physiologically based pharmacokinetics of digoxin in mdr1a knockout mice.
Masami Kawahara, Atsushi Sakata, Toshiaki Miyashita, Ikumi Tamai and Akira Tsuji J. Pharm. Sci., 88, 1281-1287 (1999)

新規Xanthine誘導体MPBXによるDoxorubicin制癌効果増強作用.
杉山朋美，佐塚泰之，澤西啓之，宮本謙一 Drug Delivery System, 14, 179-184 (1999)

組織因子(TF)又はLipopolysaccharide (LPS)によるラットDICモデルの分類と使い分けについて.
市野　典，朝倉英策，青島敬二，山崎雅英，菅　幸生，奥平真理子，森下英理子，斎藤正典，御舘靖雄，水谷朋恵，加藤みのり，宮本謙一，松田　保 血栓止血誌，10, 451-456 (1999)

薬剤管理指導で生じた薬物療法上の問題点と解決法に関するProblem Listのデータベース化と活用　ーその共同利用の提案ー.
旭　満里子，垣本倫明，西上　潤，松下　良，市村藤雄 病院薬学，25, 53-59 (1999)

治験薬有害事象に関する標準的情報項目の検討.
川井絵美，古川裕之，旭　満里子，松下　良，市村藤雄 病院薬学，25, 196-203 (1999)

注射薬液中におけるB型肝炎ウイルス抗原量とHBV-DNA量の安定性について.
松下 良，旭満里子，市村藤雄，橋本琢磨，松下栄紀，金子周一，小林健一 病院薬学，25, 621-626 (1999)